Methods and compositions relating to anthrax pathogenesis

Details Methods and compositions relating to anthrax pathogenesis Methods and compositions relating to anthrax pathogenesis

2002-11-01

2008-12-09

Navarro, Mark (Department: 1645)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S032000, C435S069200, C424S130100, C514S002600

Reexamination Certificate

active

07462472

ABSTRACT:
The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal structures, a method assaying for inhibitors of infection by a bacteria is presented which comprises obtaining a potential inhibitor, obtaining a calmodulin activated adenylyl cyclase exotoxin, obtaining calmodulin, admixing the potential inhibitor, the exotoxin, and the calmodulin, and assaying to determine whether or not the potential inhibitor inhibits production of cAMP by exotoxin.

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