Tri-and tetraaza-acenaphthylen derivatives as CRF receptor...

Details Tri-and tetraaza-acenaphthylen derivatives as CRF receptor... Tri-and tetraaza-acenaphthylen derivatives as CRF receptor...

2002-05-21

2008-11-04

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S251000

Reexamination Certificate

active

07446108

ABSTRACT:
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure:including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, R1, R2, R4, R5, R6, A, X, and Y are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

REFERENCES:
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patent: WO 00/27846 (2000-05-01), None
patent: WO 03/008414 (2003-01-01), None
Banker, Gilbert S. et al., Modem Pharmaceutics, Marcel Dekker, New York, 1996, pp. 451 and 596.
Wolff, Manfred E., Burger's Medicinal Chemistry and Drug Discovery, Fifth Ed., vol. 1: Principles and Practice, John Wiley & Sons, 1995, pp. 975-977.
Akimoto, et al., Chem. Abstracts, 1993, vol. 118, No. 21, XP002207951.
Akimoto et al. Chem. Abstracts, 118(21): 1993. XP002207951.

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