Substrates comprising polynucleotide microarrays

Details Substrates comprising polynucleotide microarrays Substrates comprising polynucleotide microarrays

1998-11-24

2008-10-28

Forman, BJ (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S174000, C435S283100, C435S287200, C422S068100, C536S023100

Reexamination Certificate

active

07442499

ABSTRACT:
A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of different DNA sequences disposed at discrete locations on a non-porous surface, at an array density of at least about 100 sequences/cm2, where the different DNA sequences in the array are effective to hybridize to individual polynucleotides in the mixture. The level of fluorescence associated with each array sequence provides a measure of its relative amount in the mixture.

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