Inhibitors of Akt activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S268400, C546S268700, C546S286000, C546S275400, C544S124000, C514S340000, C514S341000, C514S342000, C514S343000, C514S344000

Reexamination Certificate

active

07414055

ABSTRACT:
The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

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Toker et. al., “Akt Signaling and Cancer: Surviving but not Moving On”, Cancer Res 2006:66(8). Apr. 15, 2006.

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