Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-10-12
2008-10-07
Lewis, Patrick T (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S012200, C514S018700, C514S013800, C514S014800, C536S026100, C536S023200, C536S124000, C536S023100, C536S055300, C435S090000, C435S252300, C435S320100, C435S254110, C435S358000, C435S364000, C424S277100, C530S322000, C530S345000
Reexamination Certificate
active
07432246
ABSTRACT:
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2′/3′-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2′/3′-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2′/3′-O-acetyl-ADP-ribose are also provided.
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Boeke Jef D.
Celic Ivana
Sauve Anthony
Schramm Vern L.
Albert Einstein College of Medicine of Yeshiva University
Amster Rothstein & Ebenstein LLP
Lewis Patrick T
The Johns Hopkins University
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