Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-10-07
2008-10-07
Chunduru, Suryaprabha (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S024330
Reexamination Certificate
active
07432050
ABSTRACT:
This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential methylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia.
REFERENCES:
patent: 5786146 (1998-07-01), Herman et al.
patent: 6017704 (2000-01-01), Herman et al.
patent: 6200756 (2001-03-01), Herman et al.
patent: 6265171 (2001-07-01), Herman et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 7183051 (2007-02-01), Androphy et al.
patent: WO-01/68911 (2001-09-01), None
patent: WO-01/77375 (2001-10-01), None
patent: WO-01/92565 (2001-12-01), None
patent: WO-02/00927 (2002-01-01), None
Lowe et al. A computer program for selection of oligonucleotide primers for polymerase chain reactions. Nucleic Acids Research, vol. 18, No. 7, pp. 1757-1761, 1990.
Denissenko et al. Cytosine methylation determines hot spots of DNA damage in human P53 gene. Proc. Natl. Acad. Sci., vol. 94, pp. 3893-3898, 1997.
Grand et al. Frequent deletion of hSNF5/INI1, a complement of the SWI/SNF complex, in chronic myeloid leukemia. Cancer Res., Vo. 59, pp. 3870-3874, 1999.
Ahlquist, D.A. et al. Colorectal Cancer Screening by Detection of Altered Human DNA in Stool: Feasibility of Multitarget Assay Panel. Gastroenterology 119, 1219-1227 (Nov. 2000).
Deng, G. et al. Methylation of CpG in a Small Region of the hMLH1 Promoter Invariability Correlates with the Absence of Gene Expression. Cancer Res. 59, 2029-2033 (May 1, 1999).
Ding, H. et al. Characterization of a Helicase-Like Transcription Factor Involved in the Expression of the Human Plasminogen Activator Inhibitor-1 Gene. DNA Cell Biol. 15, 429-442 (1996).
Ding et al. Functional Interactions between Sp1 or Sp3 and the Helicase-like Transcription Factor Mediate Basal Expression from the Human Plasminogen Activator Inhibitor-1 Gene. J. Biol. Chem. 274, 19573-19580 (1999).
Dong, S.M. et al. Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets. J. Natl. Cancer Inst. 93, 858-865 (Jun. 6, 2001).
Esteller, M. et al. Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients. Cancer Res. 59, 67-70 (Jan. 1, 1999).
Gonzalgo, M.L. & Jones, P.A. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res. 25, 2529-2531 (1997).
Herman, J.G. et al. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. PNAS 93, 9821-9826 (Sep. 1996).
Herman, J. & Baylin, S. Methylation-Specific PCR. In Current Protocols in Human Genetics, N. Dracopoli, ed., John Wiler & Sons, Inc. vol. 2, pp. 10.6.1-10.6.10 (1998).
Hibi, K. et al. Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients. Cancer Res. 58, 1405-1407 (1998).
Kane, M.F. et al. Methylation of the hMLH1 Promoter Correlates with Lack of Expression of hMLH1 in Sporadic Colon Tumors and Mismatch Repair-defective Human Tumor Cell Lines. Cancer Res. 57, 808-811 (1997).
Mahajan, M.C. & Weissman, S. DNA-dependent adenosine triphosphatase (helicase transcription factor) activates Beta-globin transcription in K562 cells. Blood 99, 348-356 (Jan. 1, 2002).
Moinova, H.R. et al. HLTF gene silencing in human colon cancer. PNAS 99, 4562-4567 (Apr. 2, 2002).
Muchardt, C. and Yaniv, M. ATP-dependent chromatin remodeling: SWI/SNF and Co. are on the job. J. Mol. Biol. 293, 187-198 (1999).
Sanchez-Cespedes, M. et al. Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients. Cancer Res. 60, 892-895 (Feb. 15, 2000).
Silva, J.M. et al. Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br. J. Cancer 80, 1262-1264 (1999).
Sudarsanam, P. and Winston, F. The Swi/Snf family. Trends Genet. 16, 345-351 (2000).
Toyota, M. et al. CpG island methylator phenotype in colorectal cancer. PNAS 96, 8681-8686 (Jul. 1999).
Toyota, M. et al. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. PNAS 97, 710-715 (Jan. 18, 2000).
Traverso, G. et al. Detection of APC Mutations in Fecal DNA From Patients with Colorectal Tumors. N.E. J. Med. 346, 311-320 (Jan. 31, 2002).
Traverso, G. et al. Detection of proximal colorectal through analysis of faecal DNA. Lancet. 359, 403-404 (Feb. 2, 2002).
Veigl, M.L. et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. PNAS 95, 8698-8702 (Jul. 1998).
Wong, I.H.N. et al. Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients. Cancer Res. 59, 71-73 (Jan. 1, 1999).
Xiong, Z. & Laird, P.W. Cobra: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 25, 2532-2534 (1997).
Zhang, Q. et al. Molecular cloning and characterization of P113, a mouse SNF2/SWI2-related transcription factor. Gene 202, 31-37 (1997).
Hibi et al., “Methylation pattern of HLTF gene in digestive tract cancers”, Int. J. Cancer, vol. 104, pp. 433-436 (2003).
Case Western Reserve University
Chunduru Suryaprabha
Ropes & Gray LLP
LandOfFree
Methods and compositions for detecting colon cancers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for detecting colon cancers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for detecting colon cancers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4013655