DCRS5 polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S351000, C435S975000

Reexamination Certificate

active

07411041

ABSTRACT:
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.

REFERENCES:
patent: 5888774 (1999-03-01), Delcuve
patent: 6495667 (2002-12-01), Bazan
patent: 6756481 (2004-06-01), Chirica et al.
patent: 2003/0009018 (2003-01-01), Maeda et al.
patent: 2003/0082734 (2003-05-01), Dowling et al.
patent: 2005/0106673 (2005-05-01), Dowling et al.
patent: WO 00/73451 (2000-12-01), None
patent: WO 01/18051 (2001-03-01), None
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Wells, Aditivity of Mutational Effects in Proteins, 1990, Biochemistry, vol. 26, No. 37, pp. 8509-8517.
Wang et al. Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130 (1992), Genomics, vol. 14, No. 3, pp. 666-672.
Kim E. Barrett,.Baillieres Clin. Gastroenterol., 10(1):1-15, Mar. 1996. “Cytokines: sources, receptors and signalling”.
J. Fernando Bazan, et al.,Nature, 379:591, Feb. 15, 1996. “A newly defined interleukin-1?”.
J. Briscoe, et al.,Philos. Trans. R. Soc. Lond. B Biol. Sci.351(1336):167-71, Feb. 29, 1996. “JAKs, STATs and signal transduction in response to the interferons and other cytokines”.
Irwin M. Chaiken & William V. Williams,Trends Biotechnol., 14(10):369-75, Oct. 1996. “Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design”.
Thomas J. Gonda & Richard J. D'Andrea,Blood, 89(2):355-369, Jan. 15, 1997. “Activating mutations in cytokine receptors: implications for receptor function and role in disease”.
Peter C. Heinrich, et al.,Biochem. J.,334 (Pt 2):297-314, Sep. 1, 1998. “Interleukin 6-type cytokine signalling through the gp130/Jak/STAT pathway”.
Jeffrey M. Herz, et al.,J. Recept. Signal Transduct. Res.,17(5):671-776, Sep. 1997. “Molecular approaches to receptors as targets for drug discovery”.
M. Hibi, et al.,GenBank,Accession No. M57230, Jan. 6, 1995. Definition: Human membrane glycoprotein gp130 mRNA, complete cds.
James N. Ihle, et al.Stem Cells,15(Suppl 1):105-11, 1997. “Jaks and Stats in cytokine signaling”.
David E. Levy,Cytokine Growth Factor Rev.,8(1):81-90, Mar. 1997. “The house that JAK/STAT built”.
S. Lok, et al.,Database EMBL Online!, Accession No. AF178684, Sep. 10, 1999. Definition:Homo sapiensclass I cytokine receptor (zcytor5) mRNA, complete cds.
Neela Patel, et al.,J Biol Chem.,271(48):30386-30391, Nov. 29, 1996. “Functional replacement of cytokine receptor extracellular domains by leucine zippers”.
David H. Presky, et al.,Proc. Natl. Acad. Sci. USA, 93:14002-14007, Nov. 1996. “A functional interleukin 12 receptor complex is composed of two b-type cytokine receptor subunits”.
D.H. Presky, et al.,GenBank, Accession No. U64198, Nov. 28, 2000. Definition: Human IL-12 receptor beta2 mRNA, complete cds.
Olli Silvennoinen, et al.,APMIS, 105(7):497-509, Jul. 1997. “Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors”.
R.H. Waterston,Database EMBL Online!, Accession No. AC26054, Mar. 20, 2000. Definition:Homo sapienschromosome 1 clone RP11-131015, working draft sequence, 26 unordered pieces.
Linda A. Winston & Tony Hunter,Current Biology, 6(6):668-671, Jun. 1, 1996. “Intracellular signalling: Putting JAKs on the kinase MAP”.
Aggarwal, et al., (Jan. 17, 2003)J. Biol. Chem.278(3):1910-1914, “Interleukin-23 promotes a distinct CD4 T cell activation state characterized by production of interleukin-17”.
Becker, et al., (Sep. 2003)J. Clin. Invest.112:693-706, “Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells”.
Cooper, et al., (2002)J. Immunol.,168:1322-1327, “Mice lacking bioactive IL-12 can generated protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present”.
Cua, et al., (Feb. 13, 2003)Nature, 421:744-748, “Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain”.
Happel, et al., (2003)J. Immunol.170:4432-4436, “Cutting edge: roles of toll-like receptor 4 and IL-23 in IL-17 expression in response toKlebsiella pneumoniaeinfection”.
Hölscher, et al., (2001)J. Immunol.167:6957-6966, “A protective and agonistic function of IL-12p40 in mycobacterial infection”.
Krajina, et al., (2003)Eur. J. Immunol.33:1073-1083, “Colonic lamina propria dendritic cells in mice with CD4+T cell-induced colitis”.
Mahairas, et al. (1999)Proc. Nat'l. Acad. Sci. (USA)96:9739-9744, “Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome”.
Ngo, et al. (1994) “The Protein Folding Problem and Tertiary Structure Prediction” pp. 492-495.
Opalinska and Gewirtz (2002)Nat. Rev. Drug. Disc.1:503, “Nucleic-acid therapeutics: basic principles and recent applications”.
Parham, et al., (2003)J. Immunol.168:5699-5708, “A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rb1 and a novel cytokine receptor subunit, IL-23R”.
Pettit and Gombotz (1998)Trends in Biotech.16:343-349, “The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals”.
Phillips (2001)J. Pharm. and Pharmacology53:1169-1174, “The challenge of gene therapy and DNA delivery”.
Scott, et al. (1999)Nature Genetics21:440-443, “The Pendred syndrome gene encodes a chloride-iodide transport protein”.
Uhlig and Powrie (Sep. 2003)J. Clin. Invest.112(5)648-651, “Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses”.
Waldvogel, Database EMBL Online!, Accession No. AJ308426, (2001).
Wang, et al. (1992)Genomics14(3):666-672, “Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130”.
Wells (1990)Biochemistry29(37):8509-8517, “Additivity of Mutational Effects in Proteins”.
Wiekowski, et al., J. Immunol., 166:7563-7570 (2001), “Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.”

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

DCRS5 polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DCRS5 polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DCRS5 polypeptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4013321

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.