Methods of modulating angiogenesis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100

Reexamination Certificate

active

07410756

ABSTRACT:
Featured are methods of modulating angiogenesis, e.g., by modulating PKC delta. The methods are useful in the treatment of disorders characterized by aberrant and/or increased blood vessel formation and/or increased permeability. The methods are also useful for treatment a disorder characterized by abnormal, inadequate or unstable blood vessel formation or increased permeability. Also featured are diagnostic and screening methods.

REFERENCES:
patent: 5959096 (1999-09-01), Bennett et al.
Fukumoto et al (J. Biol. Chem. May 1997;272(21):13816-13822).
Lu et al (Mol Cell Biol. Jun. 1997;17(6):3418-28.).
Harrington et al., “Endothelial Proliferation, Migration, and . . . ”, Biochem Biophys Res Commun, vol. 271, No. 2, May 2000;499-508.
Kent et al., “Requirement for Protein Kinase C Activation in Basic . . . ”, Circ. Res., vol. 77, No. 2, Aug. 1995;231-238.
Koyama et al., “Tranilast inhibits protein kinase C-dependent signaling pathway . . . ”, Br. J. Pharmacol., vol. 127, No. 2, May 1999;537-45.
Yoshiji et al., “Protein Kinase C Lies on the Signaling Pathway . . . ”, Cancer Res., vol. 59, No. 17, Sep. 1999;4413-4418.
Gschwendt et al., “Differential Effects of Suramin on Protein . . . ”, Jan. 1998, FEBS Letters, vol. 421, No. 2;165-168.
Shih et al., “Role of Protein Kinase C Isoforms in Phorbol . . . ”, May 1999, J.Biol.Chem., vol. 274, No. 22;15407-15414.
U Jones et al Biochem Biophys Res Commun Aug. 1998; 249(1): 118-123.
V Jain N et al (J Biol Chem Aug. 20, 1999; 274(34): 24392-400).
W Carmeliet et al (Nature 2000; 407:249-257).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of modulating angiogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of modulating angiogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of modulating angiogenesis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4011718

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.