Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-04-26
2008-10-07
Shiao, Rei-Tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S256000
Reexamination Certificate
active
07432273
ABSTRACT:
The invention is related to phosphorus substituted antimetabolites, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
REFERENCES:
patent: 5413996 (1995-05-01), Bodor
patent: 5493030 (1996-02-01), Morgans et al.
patent: 5585397 (1996-12-01), Tung et al.
patent: 5633279 (1997-05-01), Morgans et al.
patent: 5654286 (1997-08-01), Hostetler
patent: 5670497 (1997-09-01), Bold et al.
patent: 5747498 (1998-05-01), Schnur et al.
patent: 5750343 (1998-05-01), Maag et al.
patent: 5750493 (1998-05-01), Schinazi et al.
patent: 5811422 (1998-09-01), Lam et al.
patent: 5874577 (1999-02-01), Chen et al.
patent: 5914332 (1999-06-01), Chen et al.
patent: 6072053 (2000-06-01), Vince et al.
patent: 6174888 (2001-01-01), McQuire et al.
patent: 6312662 (2001-11-01), Robinson et al.
patent: 6319946 (2001-11-01), Hale et al.
patent: 6395763 (2002-05-01), Stamos et al.
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 6767900 (2004-07-01), Ubasawa et al.
patent: 2001/0031773 (2001-10-01), Camden
patent: 2002/0119443 (2002-08-01), Becker et al.
patent: 2003/0109498 (2003-06-01), Yuasa et al.
patent: 2004/0121316 (2004-06-01), Birkus et al.
patent: 2004/0167096 (2004-08-01), Cheng et al.
patent: 0 267 050 (1988-05-01), None
patent: 0 441 192 (1991-01-01), None
patent: 0 465 297 (1992-01-01), None
patent: 0 531 597 (1993-03-01), None
patent: 0 632 048 (1995-01-01), None
patent: 0 786 455 (1997-07-01), None
patent: 0 852 233 (1998-07-01), None
patent: 0 919 562 (1999-06-01), None
patent: 1 295 879 (2003-03-01), None
patent: WO 88/06158 (1988-08-01), None
patent: WO91/19721 (1991-12-01), None
patent: WO 92/00988 (1992-01-01), None
patent: WO 92/18520 (1992-10-01), None
patent: WO 93/12123 (1993-06-01), None
patent: WO 93/24510 (1993-12-01), None
patent: WO 96/14314 (1996-05-01), None
patent: WO 96/40156 (1996-12-01), None
patent: WO 97/01558 (1997-01-01), None
patent: WO 98/04569 (1998-02-01), None
patent: WO 98/11906 (1998-03-01), None
patent: WO 98/15563 (1998-04-01), None
patent: WO 99/33815 (1999-07-01), None
patent: WO 99/62921 (1999-12-01), None
patent: WO 00/04033 (2000-01-01), None
patent: WO 00/52015 (2000-09-01), None
patent: WO 00/52015 (2001-02-01), None
patent: WO 01/13957 (2001-03-01), None
patent: WO 01/17982 (2001-03-01), None
patent: WO 01/19320 (2001-03-01), None
patent: WO 01/39724 (2001-06-01), None
patent: WO 01/46204 (2001-06-01), None
patent: WO 01/64693 (2001-09-01), None
patent: WO 01/39724 (2001-10-01), None
patent: WO 01/96329 (2001-12-01), None
patent: WO 01/96354 (2001-12-01), None
patent: WO 02/03997 (2002-01-01), None
patent: WO 02/06292 (2002-01-01), None
patent: WO 02/08241 (2002-01-01), None
patent: WO 02/14344 (2002-02-01), None
patent: WO 02/48165 (2002-06-01), None
patent: WO 02/057425 (2002-07-01), None
patent: WO 02/103008 (2002-11-01), None
patent: WO 02/100415 (2002-12-01), None
patent: WO 02/103008 (2002-12-01), None
patent: WO 03/028737 (2003-04-01), None
patent: WO 02/48165 (2003-05-01), None
patent: WO 03/050129 (2003-06-01), None
patent: WO 03/059255 (2003-07-01), None
patent: WO 03/064383 (2003-08-01), None
patent: WO 03/066005 (2003-08-01), None
patent: WO 03/080078 (2003-10-01), None
patent: WO 03/090690 (2003-11-01), None
patent: WO 2004/096234 (2004-11-01), None
patent: WO 2004/96818 (2004-11-01), None
patent: WO 2005/011709 (2005-02-01), None
patent: WO 2005/011709 (2005-02-01), None
patent: WO 2004/096818 (2005-04-01), None
Rosowsky et al., Journal of Medicinal Chemistry, 1988, 31:1326-31.
Sturtz et al., 1984, CAS:101-143560.
Allen, Lee F. et al., CI-1040 (PDI84352), a Targeted Signal Transduction Inhibitor of MEK (MAPKK),Seminars in Oncology, Oct. 2003, pp. 105-116, vol. 30, No. 5, Elsevier Inc.
Gobec, S. et al., Phosphonate inhibitors of antiget 85C, a crucial enzyme involved in the biosynthesis of the mycobacterium tuberculosis cell wall,Bioorganic and Medicical Chemistry Letters, 2004, vol. 14.
Hegedus, Louis S. et al., Synthesis of 4′-Methyl and 4′-cyano Carbocyclic 2′,3′-Didehydro Nucleoside Analogues via 1,4-Addition to Substituted Cyclopentenones,J. Org. Chem., 2004, 8492-8495, vol. 69, No. 24, American Chemical Society.
Herczegh P., et al., Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterials,J. Med. Chem., 2002, vol. 45.
Hirabayashim Hideki et al., Bone-Specific Drug Delivery Systems,Clinical Pharacokinetics, 2003, 1319-1330, vol. 42, No. 15.
Holy A. et al., Synthesis,Cllect. Czech. Chem. Commun., 1989, vol. 54, pp. 2190-2210.
Jain, Jugnu et al., Characterization of Pharmacological Efficacy of VX-148, a New, Potent Immunosuppressive Inosine 5′-Monophosphate Dehydrogenase Inhibitor,Journal of Pharmacology and Experimental Therapeutics, 2002, 1272-1277, vol. 302, No. 3, The American Society for Pharmacology and Expermental Therapeutics.
Karpenko, Inna L. et al., Synthesis and Antitherpetic Activity of Acyclovir Phosphonates,Nucleosides, Nucleotides&Nucleic Acids, 2003, 319-328, vol. 22, No. 3, Marcel Dekker, Inc.
Kato, Keisuke et al., Stereoselective synthesis of 4′ -.alpha.-alkyclcarbovir derivatives based on an asymmetric synthesis or chemo-enzymatic procedure,Chemical&Pharmaceutical Bulletin, 1999, 1256-1264, vol. 49, No. 9, Pharmaceutical Society of Japan.
Kato, Keisuke et al. Enantio- and diastereoselective synthesis of 4′-α-substituted carbocyclic nucleosides, Tetrahedron:Asymmetry, 1998, 911-914, vol. 9, Elsevier Science Ltd.
Kilpatrick, J. Michael, Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor, In vivo effects on blood 2′-deoxyguanosine in primates,International Immunopharmacology, 2003, 541-548, vol. 3, Elsevier Science B.V.
Kim, Choung Un et al., Regiospecific and Highly Stereoselective Electrophilic Addition to Furanoid Glycals: Synthesis of Phosphonate Nucleotide Analogues with Potent Activity against HIV, J. Org. Chem., 1991, 2642-2647, vol. 56, No. 8, American Chemical Society.
Kinsky, Stephen C. et al., Inhibitor of cell proliferation by putative metabolites and nondegrable analogs of methotrexate-.gama.-dimyristoylphosphatidylethanolamine,Biochimica et Biphysica Acta, 19878, 211-218, vol. 917, No. 2., Elsevier Science Publishers B.V.
Kinsky, Stephen C. et al., Effect of liposomes sentitized with methotrexate-γ-dimyristoylphosphatidylethanolamine on cells that are resistant to methotrexate,Biochimica et Biophysica Acta, 1986, 129-135, vol. 885, Elsevier Science Publishers B.V.
Kinsky, Stephen C. et al., Circumvention of the methotrexate transport system by methotrexate-phosphatidylethanolamine derivatives effect of fatty acid chain length,Biochimica et Biophysica Acta, 1987, 96-103, vol. 921, Elsevier Science Publishers B.V.
Ko, Ok Hyun et al., Efficient synthesis of novel carbocyclic nucleosides via sequential Claisen rearrangement and ring-closing metathesis,Tetrahedron Letters, 2002, 6399-6402, vol. 43, Elsevier Science Ltd.
Reed, Leff et al., Antidiabetic PPARγ Ligands: An update on Compounds in development,Curr. Med. Chem.—Imun., Endoc.&Metab. Agents, 2002, 33-47, vol. 2, No. 1, Bentham Science Publishers Ltd.
Lewandowicz, Andrzej et al., Achieving the Ultimate Physiological Goal in Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase,The Journal of Biological Chemistry, 2003, 31465-31468, vol. 278, No. 34, The American Society for Biochemistry and Molecular Biology, Inc.
Pankiewicz, Krzysztof W., Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents Human Leukemia,J. Med. Chem., 2002 703-712, vol. 45, No. 3, American Chemical Society.
Ono-Nita, Suzane Kioko et al., Novel Nucleoside Analogues MCC-478 (LY52563) Is Effective against Wild-Type or Lamivudine-Resistant Hepatitis B Virus,Antimicrobial Agents and Chemotherapy, 2002, 2602-2605, vol. 46, No. 8, American Society for Microbiology.
Parang, Keykavous et al., Novel Approaches f
Fardis Maria
Kirschberg Thorsten
Watkins William J.
Gilead Sciences, Inc.
Shiao Rei-Tsang
Viksnins Harris & Padys PLLP
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