Process for preparation of maytansinol

Details Process for preparation of maytansinol Process for preparation of maytansinol

2006-11-08

2008-08-12

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07411063

ABSTRACT:
The present invention describes the preparation of maytansinol by methods that minimize processing steps, and reduce solvent volumes, making the process more efficient, and scaleable. This process comprises a step of converting bridged acetals of maytansinol to maytansinol. The simplified processing also aids in lowering the potential for human exposure to chemicals. Also provided is an isolated C3 to C9 bridged acetal of maytansinol.

REFERENCES:
patent: 6333410 (2001-12-01), Chari et al.

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