Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2004-08-25
2008-08-05
Minnifield, N. M (Department: 1645)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S048000, C514S002600, C514S008100, C514S045000, C514S046000, C514S047000, C424S184100, C424S234100, C424S204100, C424S265100, C424S274100, C424S278100, C424S277100, C424S275100, C536S023100
Reexamination Certificate
active
07407944
ABSTRACT:
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
REFERENCES:
patent: 5149798 (1992-09-01), Agrawal et al.
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5495006 (1996-02-01), Climie et al.
patent: 5635377 (1997-06-01), Pederson et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 5668265 (1997-09-01), Nadeau et al.
patent: 5856462 (1999-01-01), Agrawal
patent: 5912332 (1999-06-01), Agrawal et al.
patent: 6143881 (2000-11-01), Metelev et al.
patent: 6172208 (2001-01-01), Cook
patent: 6218371 (2001-04-01), Krieg et al.
patent: 6346614 (2002-02-01), Metelev et al.
patent: 6683167 (2004-01-01), Metelev et al.
patent: 6815429 (2004-11-01), Agrawal
patent: 7045609 (2006-05-01), Metelev et al.
patent: 7074768 (2006-07-01), Agrawal
patent: 7115579 (2006-10-01), Agrawal et al.
patent: 7276489 (2007-10-01), Agrawal et al.
patent: 7329648 (2008-02-01), Agrawal
patent: 7354907 (2008-04-01), Agrawal et al.
patent: 2003/0175731 (2003-09-01), Fearon et al.
patent: 2003/0199466 (2003-10-01), Fearon et al.
patent: 2006/0014713 (2006-01-01), Agrawal et al.
patent: 2006/0019909 (2006-01-01), Agrawal et al.
patent: 2006/0217328 (2006-09-01), Kandimalla et al.
patent: 2006/0287262 (2006-12-01), Agrawal et al.
patent: 2007/0049550 (2007-03-01), Fearon et al.
patent: 2007/0173469 (2007-07-01), Agrawal et al.
patent: 2007/0179103 (2007-08-01), Agrawal et al.
patent: 2007/0219153 (2007-09-01), Kandimalla et al.
patent: 2008/0089883 (2008-04-01), Kandimalla et al.
patent: 1393745 (2004-03-01), None
patent: WO97/29757 (1997-08-01), None
patent: WO 98/49288 (1998-11-01), None
patent: WO 01/12804 (2001-02-01), None
patent: WO 01/55370 (2001-08-01), None
patent: WO 01/83503 (2001-11-01), None
patent: WO 02/26757 (2002-04-01), None
patent: WO03/000922 (2003-01-01), None
patent: WO03/035836 (2003-05-01), None
patent: WO 2007/084237 (2007-07-01), None
Agrawal et al., “Protocols for Oilgonucleotides and Analogs”, Methods in Molecular Biology, 20:165-189, 1993.
Uhlmann et al., Oligonucleotides and Analogues, a Practical Approach, pp. 87-108, 1991.
Agrawal et al., Curr. Op. in biotech., 6:12, 1995.
Crooke et al., Antisense Research and Applications, CRC Press, Boca Raton, 1993.
Khorana et al., J. Molec. Biol., 72:209, 1972.
Reese, Tetrahedron Lett., 34:3143-3179, 1978.
Beaucage et al., Tetrahedron Lett. 22:1859-1862, 1981.
Agrawal et al., Tetrahedron Lett., 28:3539-3542, 1987.
Connolly et al., Biochem., 23:3443, 1984.
Jager et al., Biochem., 27:7237, 1988.
Agrawal et al., Proc. Natl. Acad. Sci. (USA), 85:7079-7083, 1988.
Kuramoto et al., Jpn. J. Cancer Res., 83:1128-1131, 1992.
Krieg et al., Nature, 371:546-549, 1995.
Liang et al., J. Clin. Invest., 98:1119-1129, 1996.
Moldoveanu et al., Vaccine, 16:1216-124, 1998.
McCluskie et al., J. Immunol., 161:4463-4466, 1998.
Zhao et al., Biochem. Pharmacol., 51:173-182, 1996.
Zhao et al., Biochem. Pharmacol., 52:1537-1544, 1996.
Zhao et al., Antisense Nucleic Acid Drug Dev., 7:495-502, 1997.
Zhao et al., Bioorg. Med. Chem. Lett., 9:3453-3458, 1999.
Zhao et al., Bioorg. Med. Chem. Lett., 10:1051-1054, 2000.
Yu et al., Bioorg. Med. Chem. Lett., 10:2585-2588, 2000.
Yu et al., Bioorg. Med. Chem. Lett. 11:2263-2267, 2001.
Kandimalla et al., Bioorg. Med. Chem., 9:807-813, 2001.
Remington's Pharmaceutical Sciences, 18thEdition, ed. A. Gennaro, Mack Publishing Co., Easton, PA, 1990.
Noronha et al., Biochem., 39:7050-7062, 2000.
International Search Report issued in corresponding PCT application PCT/US02/34247.
European Search Report issued in corresponding European application 03017211.8.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar R.
Yu Dong
Idera Pharmaceuticals Inc.
Keown Wayne A.
Keown & Zucchero, LLP
Minnifield N. M
Zucchero Joseph C.
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