Heterocyclic compounds

Details Heterocyclic compounds Heterocyclic compounds

2006-10-03

2008-08-12

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S232500, C544S080000, C548S304400, C548S304700

Reexamination Certificate

active

07410990

ABSTRACT:
This invention features a compound of formula (I):R1is aryl or heteroaryl; each of R2and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)RbNRaS(O)2Rb, NRaC(O)NRbRc, NRaC(S)NRbRc, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NRaRb, S(O)2NRaRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRb; R5is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O)2, or NRe; B is N or CRf; X is O, S, S(O), S(O)2, NRe, or C(O); Y is a covalent bond, C(O), C═NRa, O, S, S(O), S(O)2, or NRe; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NRe; in which each of Ra, Rb, Rc, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Reis H, alkyl, aryl, acyl, or sufonyl; and Rfis H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.

REFERENCES:
patent: 4459296 (1984-07-01), Ancher et al.
patent: 4946843 (1990-08-01), Janssens et al.
patent: 5864037 (1999-01-01), Chasin et al.
patent: 6384032 (2002-05-01), Ono et al.
patent: 6680733 (2003-12-01), Sun et al.
patent: 6680315 (2004-01-01), Ono et al.
patent: 6693097 (2004-02-01), Ono et al.
patent: 7045517 (2004-03-01), Ono et al.
patent: 7067514 (2004-03-01), Ono et al.
patent: 6858606 (2005-02-01), Sun et al.
patent: 6958332 (2005-10-01), Sun et al.
patent: 7122665 (2006-10-01), Sun et al.
patent: 2005/0250787 (2005-11-01), Sun et al.
patent: 2006/0025409 (2006-02-01), Ono et al.
patent: WO 9926932 (1999-06-01), None
patent: WO-00/78757 (2000-12-01), None
patent: WO-2005/000404 (2005-01-01), None
Barrie et al. (Clinical and Applied Immunology Reviews 2005, 5, 225-240).
Comabella et al. (J. Clin. Invest. 1998, 102(4), 671-678).
Schmidt et al. (Pathobiology 2002-03, 70, 177-183).
Adorini, L. (Nature Genetics 2001, 27, 131-132).

Affiliated with

Also associated with

Rating

Heterocyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4002716