Therapeutic compositions of oncomodulin

Details Therapeutic compositions of oncomodulin Therapeutic compositions of oncomodulin

2007-05-17

2008-08-05

Spector, Lorraine (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07407937

ABSTRACT:
The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.

REFERENCES:
patent: 2720069 (1995-11-01), None
patent: WO 97/03188 (1997-01-01), None
patent: WO 97/34618 (1997-07-01), None
patent: WO 00/13705 (2000-03-01), None
patent: WO 01/11086 (2001-02-01), None
Conner, J.M., et al., 2001, “Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation”, PNAS 98 (4): 1941-1946.
Pauls, T.L., et al., 1996, “The Ca2+-binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings”, Biochim. Biophys. Acta 1306: 39-54.
Kawamata, T. et al., 1997, “Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction”, PNAS 94: 8179-84.
Ritzler, J.M., et al., 1992, “The genes for the highly homologous Ca2+-binding proteins oncomodulin and parvalbumin are not linked in the human genome”, Genomics 12: 567-572.
Weidner, N., et al., 2001, “Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury”, PNAS 98 (6): 3513-18.
Flanders, K.C., et al., 1998, “Transforming growth factor-betas in neurodegenerative disease”, Progress in Neurobiology 54 (1): 71-85.
Di Iorio, P. et al., 2001, “Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor-mediated mechanisms”, Drug Development Research 52 (1-2): 303-315.
Poulsen, K.T., et al., 1994, “TGF-beta2 and TGF-beta3 are potent survival factors for midbrain dopaminergic neurons”, Neuron 13 (5): 1245-52.
English Abstract of FR 2720069.
Durkin et al., Cancer Research, vol. 43, pp. 5390-5394, 1983.
Yin et al., Nature Neuroscience, vol. 19, pp. 843-852, 2006 (Abstract Only).

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