Ligands for asymmetric reactions

Details Ligands for asymmetric reactions Ligands for asymmetric reactions

2006-06-23

2008-08-05

Shameem, Golam M. M. (Department: 1626)

Catalyst, solid sorbent, or support therefor: product or process

Catalyst or precursor therefor

Phosphorus or compound containing same

C548S300100

Reexamination Certificate

active

07407910

ABSTRACT:
The invention relates to a process for the manufacture of bidentate ligands of the formula IA and IIA, characterized in that N,N-(optionally substituted) dialkylamino phosphines bound to an aromatic carbon are lithiated in ortho-position and the lithiated compounds are further converted to said bidentate ligands:wherein X1is NR, O or S; X2is CHR1or CR1; X3is CHR2or NR2or, if X2is CR1, X3is CR2or N; and R, R1and R2are radicals such as alkyl groups or R1and R2together form an annealed ring; Y1*, Y2* and Y1′* are, independently of each other, an element of the fifth group of the periodic table of elements as such or in thioxo or oxo form; Z1*, Z2*, Z3*, Z4*, Z1′*, Z2′* are, independently of each other, for example halogen, hydrogen, or an unsubstituted or substituted moiety selected from radicals such as alkyl groups; the substituents have otherwise the meanings given in the specification; and the ligands are capable of forming metal complexes, which can be used as catalysts in stereoselective synthesis, especially hydrogenation, of various organic molecules.

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