Inhibitors of cruzipain and other cysteine proteases

Details Inhibitors of cruzipain and other cysteine proteases Inhibitors of cruzipain and other cysteine proteases

2002-01-17

2008-09-16

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S301000, C514S302000, C514S412000, C546S113000, C546S114000, C546S115000, C548S453000

Reexamination Certificate

active

07425562

ABSTRACT:
Compounds of general formula (I) or general formula (II)wherein R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.

REFERENCES:
patent: 3652574 (1972-03-01), Garmaise
patent: 98/05336 (1998-02-01), None
patent: 98/08802 (1998-03-01), None
patent: 98/28268 (1998-07-01), None
patent: 98/50533 (1998-11-01), None
patent: 99/53039 (1999-10-01), None
patent: 00/29408 (2000-05-01), None
patent: 02/40462 (2000-05-01), None
patent: 00/69855 (2000-11-01), None
patent: 02/051983 (2002-07-01), None
Fenwick, et al., “Diastereoselective Synthesis, Activity and Chiral Stability of Cyclic Alkoxyketone Inhibitors of Cathepsin K,”Bioorganic&Medicinal Chemistry Letters, vol. 11, pp. 199-202 (2001).
Marquis, et al., “Conformationally Constrained 1, 3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin K,”J. Med. Chem., vol. 41, pp. 3563-3567 (1998).

Affiliated with

Also associated with

Rating

Inhibitors of cruzipain and other cysteine proteases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of cruzipain and other cysteine proteases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of cruzipain and other cysteine proteases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3990873