Pyridinalkyl-aminoalkyl-IH-indole derivatives having an...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S337000, C546S164000, C546S176000, C546S277400

Reexamination Certificate

active

07432282

ABSTRACT:
Novel indole derivatives of the formula (I), in which X, Y, R1, R1′, m and n have the meanings indicated in Patent Claim 1, have a strong affinity to the 5-HT1Aand in some cases to the 5-HT1Dreceptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics and for the treatment of neurodegenerative diseases

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Vacher, Bernard et al.: “Design and Synthesis of a series of 6-Substituted 2-Pyridinylmethylamine Derivatives as Novel, High-Affinity, Selective Agonists at 5 - HT1A Receptors” Journal of Medicinal Chemistry (1998), Seite 1, verbindung 77, Seite 5075.
Yajima, Tatsuo et al.: “Conformational Preference of the Side Chain Aromatic Ring in Cu(II) and Pd(II) Complexes of 2N10-Donor Ligands” Inorganica Chimica Acta (2002), seite 195.

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