Sulphonic acid salt of sibutramine

Details Sulphonic acid salt of sibutramine Sulphonic acid salt of sibutramine

2006-01-06

2008-09-30

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S283000, C564S289000, C514S650000

Reexamination Certificate

active

07429679

ABSTRACT:
Disclosed is a novel sulphonic acid salt of sibutramine, which has good physicochemical properties. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.

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Database Caplus, Accession No. 2004:690574, Document No. 141:179571, record for Athayde, A., “Preparation of sibutramine hydrogensulfate,” Brazilian Patent Application No. 2001005486, (2003).
Database Delphion, record for Athayde, A., “Process is for obtaining sulphate of 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-cyclobutanomethamine and its isomers,” Brazilian Patent Application No. 2001000005486, (2003).
Database Caplus, Accession No. 1987:623314, Document No. 107:223314, record for Jeffrey et al., “N-N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate for use in treating depression,” Great Britian Patent No. 2184122, (1987).
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Database Caplus, Accession No. 2001:565912, Document No. 135:111957, record and English language abstract for Fu et al., “Preparation of monohydrate of N,-N-dimethyl-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutylamine hydrochloride,” Chinese Patent No. 1125032, (2003).

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