Membranes incorporating recognition moieties

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

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Details

C435S287100, C435S287200, C436S528000

Reexamination Certificate

active

07371585

ABSTRACT:
The present invention provides a thiosulfonate-activated ionophore comprising an ionophore, a spacer group, and an alkylthiosulfonate moiety. A preferred ionophore is gramicidin A. A preferred alkylthiosulfonate is methanethiosulfonate. The present invention also provides a conjugate comprising an ionophore, a spacer group, and a recognition molecule. Further the invention related to membranes incorporating the conjugates and biosensors comprising said membranes.

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patent: 5741409 (1998-04-01), Raguse et al.
patent: 5741712 (1998-04-01), Cornell et al.
patent: 5753093 (1998-05-01), Raguse et al.
patent: 5874316 (1999-02-01), Cornell et al.
patent: 6291155 (2001-09-01), Raguse et al.
patent: 6316273 (2001-11-01), King et al.
patent: WO 98/55853 (1998-12-01), None
patent: WO 00/47548 (2000-08-01), None
patent: WO 02/079394 (2002-10-01), None

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