Modulation of Aurora B expression

Details Modulation of Aurora B expression Modulation of Aurora B expression

2005-05-24

2008-05-20

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C514S04400A, C536S023100, C536S024100

Reexamination Certificate

active

07375212

ABSTRACT:
Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using these compounds for modulation of Aurora B expression and for diagnosis and treatment of diseases and conditions associated with expression of Aurora B are provided. Also provided are methods of using these compounds to modulate the growth of cancer cells, including p53-deficient cancer cells.

REFERENCES:
patent: 5998148 (1999-12-01), Bennett et al.
patent: 6759212 (2004-07-01), Tatsuka et al.
patent: 2005/0107386 (2005-05-01), Narla et al.
Adams, R. R. et al., “Chromosomal passengers and the (aurora) ABCs of mitosis,”Trends in Cell Biol. (2001) 11(2):49-54.
Andrews, P. D. et al., “Aurora B Regulates MCAK at the Mitotic Centromere,”Dev. Cell. (2004) 6:253-268.
Carmena, M. et al., “The Cellular Geography of Aurora Kinases,”Nature Rev. Mol. Cell. Biol. (2003) 4:842-854.
Chen, J. et al., “Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells,”J. Biol. Chem. (2003) 278(1):486-490.
Giet, R. et al., “Aurora/Ip11p-related kinases, a new oncogenic family of mitotic serine-threonin kinases,”J. Cell. Sci. (1999) 112:3591-3601.
Giet, R. et al., “DrosophilaAurora B Kinase is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis,”J. Cell. Biol. (2001) 152(4):669-681.
Harrington, E. A. et al., “VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo,”Nature Med. (2004) 10(3):262-267.
Hauf, S. et al., “The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint,”J. Cell Biol. (2003) 161(2):281-294.
Honda, R. et al., “Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis,”Mol. Biol. Cell(2003) 14:3325-3341.
Lampson, M. A. et al., “Correcting improper chromosome-spindle attachments during cell division,”Nature Cell Biol. (2004) 6(3):232-237.
Lampson, M. A. et al., “The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments,”Nature Cell Biol. (2005) 7(1):93-98.
Murata-Hori, M. et al., “The Kinase Activity of Aurora B is Required for Kinetochore-Microtubule Interactions during Mitosis,”Curr. Biol. (2002) 12:894-899.
Shannon, K. B. et al., “Chromosome Dynamics: New Light on Dispatch Aurora B Kinase Function,”Curr. Biol. (2002) 12:R458-R460.
Shindo, M. et al., “cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2,”Biochem. Biophys. Res. Comm. (1998) 244:285-292.
Tatsuka, M. et al., “Multinuclearity and Increased Ploidy Caused by Overexpression of the Aurora- and Ip11-like Midbody-associated Protein Mitotic Kinase in Human Cancer-Cells,”Cancer Res. (1998) 58(21):4811-4816.
Terada, Y. et al., “AIM-1:a mammalian midbody-associated protein required for cytokinesis,”EMBO J. (1998) 17(3):667-676.
Wheatley, S. P. et al., “Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo,”J. Biol. Chem. (2004) 279(7):5655-5660.
Zeitlin, S. G. et al., “CENP—A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis,”J. Cell Biol. (2001) 155(7):1147-1157.

Affiliated with

Also associated with

Rating

Modulation of Aurora B expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of Aurora B expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of Aurora B expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3981595