Efficient methods for solid phase synthesis using trityl...

Details Efficient methods for solid phase synthesis using trityl... Efficient methods for solid phase synthesis using trityl...

2002-03-29

2008-09-23

Epperson, Jon D (Department: 1639)

Combinatorial chemistry technology: method, library, apparatus

Method of creating a library

Solid-phase synthesis or particular method of cleavage from...

C528S422000, C564S305000

Reexamination Certificate

active

07427260

ABSTRACT:
Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a library of discrete chemically modified amino derivatives also disclosed.

REFERENCES:
patent: 5198531 (1993-03-01), Webber et al.
patent: 5952497 (1999-09-01), Carey
patent: 6251583 (2001-06-01), Zhang et al.
Matrins et al., “Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Eptoposide-induced Apoptosis” J. Biol. Chem. 1997, 11, 7421-7430.
Stavropoulos et al. “Preparation of polymer-bound trityl-hydrazines and their application in the solid phase synthesis of partially protected peptide hydrazides” Lett. Pept. Sci. 1994, 2, 315-318.
Carlson et al., “Solid-Phase Synthesisof Acridine-Based Threading Intercalator Peptides” Bioorg. Med. Chem. Lett. 2000, 10, 1979-1982.
Green, M. A. “Receptor-Targeted Metalloradiopharmaceuticals”, Final Technical Report DE-FG02-97ER62340, 2000, pp. 2-25.
Bunin, B. A. The Combinatorial Index. New York: Academic Press. 1998, pp. 24, 25, 52, 53, 54, 55, and 129.
Solomons, T. W. G. Organic Chemistry Fifth Edition. New York: John Wiley and Sons. 1992, p. 242.
Matrins et al., “Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Eptoposide-induced Apoptosis” J. Biol. Chem. 1997, 11, 7421-7430.
Stavropoulos et al. “Preparation of polymer-bound trityl-hydrazines and their application in the solid phase synthesis of partially protected peptide hydrazides” Lett. Pept. Sci. 1994, 2, 315-318.
Carlson et al., “Solid-Phase Synthesisof Acridine-Based Threading Intercalator Peptides” Bioorg. Med. Chem. Lett. 2000, 10, 1979-1982.
Barlos et al., “Darstellung Geschützter Peptid-Fragmente Unter Einsatz Substituierter Triphenylmethyl-Harze,”Tetrahedron Lett.,1989, 30:3943-3946 (English summary included).
Barlos et al., “Application of 4-Polystryryltriphenylmethyl Chloride to the Syntheses of Peptides and Amino Acid Derivatives,”Liebigs Ann. Chem.,1988, 1079-1081 (English summary included).
Bunin,The Combinatorial Index,Academic Press, San Diego, 1998 (TOC only).
Chen et al., ““Analogous” Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis,”J. Am. Chem. Soc.,1994, 116:2661-2662.
Guan et al., “Synthesis of Compound Libraries Based on 3,4-Diaminocylopentanol Scaffolds,”Journal of Combinatorial Chemistry, 2000, 2(4):297-300.
Leznoff, “The Use of Insoluble Polymer Supports in General Organic Synthesis,”Acc. Chem. Res.,1978, 11:327-333.
Nambara et al., “Protein farnesylation in plants: a greasy tale,”Current Opinion in Plant Biology,1999, 2:388-392.
Perola et al., “Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads,”J. Med. Chem.,2000, 43:401-408.

Affiliated with

Also associated with

Rating

Efficient methods for solid phase synthesis using trityl... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Efficient methods for solid phase synthesis using trityl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Efficient methods for solid phase synthesis using trityl... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3979505