Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-02-08
2008-03-04
Rawlings, Stephen L. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100
Reexamination Certificate
active
07338758
ABSTRACT:
The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
REFERENCES:
Abuharbeid et al. (Naunyn-Schmidedberg's Arch. Pharmacol. 2005; 371: 141-151).
Ayers et al. (J. Clin. Oncol. Jun. 15, 2004; 22 (12): 2284-2293).
Brown Jeffrey L.
Clark Edwin
Grenfell-Lee Tallessyn
Hartmann Lynn
Lu Karen
Board of Regents, The University of Texas System.
Lahive & Cockfield LLP
Maria Laccotripe Zacharakis
Mayo Foundation for Medical Education And Research.
Millennium Pharmaceuticals Inc.
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