Tissue-specific transporter inhibitor

Details Tissue-specific transporter inhibitor Tissue-specific transporter inhibitor

2003-12-19

2008-09-02

Rao, Manjunath (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S078080, C424S078180, C424S078190, C536S001110

Reexamination Certificate

active

07420029

ABSTRACT:
The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a therapeutic drug for suppressing the progress of chronic renal failure containing the inhibitor as an active ingredient. A tissue-specific transporter inhibitor which is not absorbed through the digestive tract is constructed by introducing a dipeptide which is a ligand of an oligopeptide transporter 1 into a supramolecular structure polyrotaxane wherein its structurally modified active residue is expected to be excellent in the interaction with a transmembrane transporter.

REFERENCES:
patent: WO 98/07449 (1998-02-01), None
Inui et al., Physiological and pharmalogical implications of peptide transporters, PEPT1 and PEPT2, 2000, Nephrology Dialysis Transplant, vol. 15, Suppl 6, pp. 11-13.
Takahashi et al., Upregulation of H+-peptide cotransporter PEPT2 in rat remnant kidney, 2001, American Journal Physiology Renal Physiology, vol. 281, pp. F1109-F1116.
Tooru Ooya, et al., New Concept Of Multivalent Ligands: Polyrotaxane-Dipeptide Conjugates As A Specific Inhibitor Of Intestinal Peptide Transporter Pept1, Polymer Preprints, 2001, 42(2), p. 135-136.
Tami, Ikumi, Membrane Transporters As Determinant Of Drug Absorption And Disposition, (Abstract), Yakubutsu Dotai, 1996, 11(6), p. 642-650.
I. Tamai, et al., Retardation Of Progressive Chronic Renal Disease By Polyrotaxane-Dipeptide Conjugate That Inhibits Intestinal Peptide Transporter Pept1, Proceedings Int'l Symp. Control Rel. Bioact. Mater., 2001, 28, p. 1275-1276.
Nobuhiko Yui, et al., Inhibitory Effect Of Supramolecular Polyrotaxane-Dipeptide Conjugates On Digested Peptide Uptake Via Intestinal Human Peptide Transporter, Bioconjugate Chem., 2002, 13, p. 582-587.
Tooru Ooya, et al., New Concepts Of Multivalent Ligands; Polyrotaxane-Dipeptide Conjugates As A Specific Inhibitor Of Intestinal Peptide Transporter Pept1, (Abstract), 222NDACS National Meeting, American Chemical Society, Chicago IL, Aug. 26-30, 2001.
N. Najwa et al., “New Molecular Targets for Cholesterol-Lowering Therapy”, J. Pharmacol. Exp. Ther., vol. 293, No. 2, pp. 315-320, Feb. 1, 2000.
Shimizu et al. Am J Physiol Gastrointest Liver Physiol. 288: G664-670, 2005.
Ooya T, Yamashita A, Kurisawa M, Sugaya Y, Maruyama A, Yui N. Effects of polyrotaxane structure on polyion complexation with DNAScience and Technology of Advanced Materials5: 363-369, 2004.
Ooya, T, Eguchi M, Yui N. Supramolecular design for multivalent interaction: maltose mobility along polyrotaxane enhanced binding with concanavalin A.Journal of American Chemical Society125: 13016-13017, 2003.
Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Kogure K, Ito R, Harashima H. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery.Journal of American Chemical Society128: 3852-3853, 2006.
Eguchi M, Ooya T, Yui N. Controlling the mechanism of trypsin inhibition by the numbers of α-cyclodextrins and carboxyl groups in carboxyethylester-polyrotaxanes.Journal of Controlled Release96: 301-307, 2004.
Yamashita A, Yui N, Ooya T, Kano A, Maruyama A, Akita H, Kogure K, Harashima H. Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid non-viral delivery of pDNA to cell nuclei.Nature Protocol1: 2861-2869, 2007.
Ooya T, Utsunomiya H, Eguchi M, Yui N. Rapid binding of concanavalin A and maltose-polyrotaxane conjugates due to mobile motion of α-cyclodextrins threaded onto a poly(ethylene glycol).Bioconjugate Chemistry16: 62-69, 2005.

Affiliated with

Also associated with

Rating

Tissue-specific transporter inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue-specific transporter inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue-specific transporter inhibitor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3971748