Polynucleotide encoding a mouse choline transporter

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S235100, C435S252300, C435S320100, C536S023500, C530S350000

Reexamination Certificate

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07338799

ABSTRACT:
Human high affinity choline transporter (CHT) cDNA was cloned from spinal cord and the primary structure and chromosomal localization have been determined. Mouse high affinity CHT cDNA was also cloned and characterized. An isolated polynucleotide, an isolated polypeptide, a recombinant host cell, a recombinant vector, a purified protein, an antibody, a nucleic acid detection kit, a method for screening cholinergic therapeutics, a method of treating a patient, a method of gene therapy and transgenic CHT mice are discussed.

REFERENCES:
patent: 5658786 (1997-08-01), Smith et al.
patent: 6500643 (2002-12-01), Wu et al.
patent: 2382464 (2002-02-01), None
patent: 10009055 (2001-08-01), None
patent: WO-0116315 (2001-03-01), None
Kaufman et al. Blood 94: 3178-3184, 1999.
Wang et al. Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res 27(23): 4609-4618, 1999.
Invitrogen 2001 catalog, p. 155.
Ferguson et al. Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Proc Natl Acad Sci U S A. 101(23):8762-8767, 2004.
Apparsundaram et al., “Immunocytochemical localization of hemicholinium-3-sensitive choline transporters,”Soc. For Neuroscience, ABSTRACT,Nov. 10-15, 2001, San Diego.
Apparsundaram et al., “Molecular cloning and characterization of human and murine high-affinity choline transporters,”Soc. Neurosci., ABSTRACT, 26:15350, 2000. Abstract found at the Society for Neuroscience website. www.nfs.org, Dec. 26, 2001.
Apparsundaram et al., “Molecular cloning and characterization of a murine, hemicholinium-3-sensitive choline transporter,”Biochemical Society Transactions, 29(6):711-716, 2001.
Apparsundaram et al., “Molecular cloning of a human, hemicholinium-3-sensitive choline transporter,”Biochem. Biophys. Res. Communications, 276:862-867, 2000.
Barnwell et al., “Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA
oradrenaline neurotransmitter transporter family,”Gene, 159:287-288, 1995.
Bork et al., “Go hunting in sequence databases but watch out for the traps,”Trends in Genetics, 12(10):425-427, 1996.
Bork, “Powers and pitfalls in sequence analysis: the 70% hurdle,”Genome Res., 10:398-400, 2000.
Brenner, “Errors in genome function,”Trends in Genetics, 15(4):132-133, 1999.
Dai et al., “Cloning and characterization of the thyroid iodide transporter,”Nature, 379:458-459, 1996.
Doerks et al., “Protein annotation: detective work for function prediction,”Trends in Genetics, 14(6):248-250, 1998.
Ferguson et al., “Regulated subcellular localization of high-affinity choline transporters (CHTs) supported by protein phosphatase 2A interactions,”Soc. For Neuroscience, ABSTRACT, Nov. 10-15, 2001, San Diego.
Fisher et al., “Transport of choline by plasma membrane vesicles from lung-derived epithelial cells,”Am. J. Physiol., 263(6 pt 1):C1250-1257, 1992.
GenBank Accession No. AB030947, Okuda et al., Feb. 2000.
GenBank Accession No. AB043997, Okuda et al., Nov. 2000.
GenBank Accession No. AC009933, Heath, Jul. 2001.
GenBank Accession No. AC009963, Waterston, Aug. 2001.
GenBank Accession No. AC023672, Waterston, Nov. 2001.
GenBank Accession No. AF276871, Apparsundaram et al., Nov. 2000.
GenBank Accession No. AF276872, Apparsundaram et al., Feb. 2001.
GenBank Accession No. AJ401466, Wieland et al., Aug. 2000.
GenBank Accession No. Z17178, Weissenbach, Nov. 1994.
GenBank Accession No. Z23978, Weissenbach, Nov. 1994.
GenBank Accession No. Z53730, Weissenbach, Mar. 1996.
Guimbal and Kilimann, “A Na+-dependent creatine transporter in rabbit brain, muscle, heart, and kidney,”J Biol Chem, 268(12):8418-8421, 1993.
Hediger et al., “Expression cloning and cDNA sequencing of the Na+/glucose co-transporter,”Nature, 330:379-381, 1987.
Lockman et al., “The transport of choline,”Drug Develop. Indust. Pharm., 28(7):749-771, 2002.
Mayser et al., “Primary structure and functional expression of a choline transporter expressed in the rat nervous system,”FEBS, 305(1):31-36, 1992.
Ngo et al., “Computational complexity, protein structure prediction, and the Levinthal paradox,”The Protein Folding Problem and Tertiary Structure Prediction, 492-495, 1994.
Nikawa et al., “Primary structure of the yeast choline transport gene and regulation of its expression,”J. Biol. Chem., 265(26):15996-16003, 1990.
O'Regan et al., “An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins,”PNAS, 97(4):1835-1840, 2000.
Okuda and Haga, “Functional characterization of the human high-affinity choline transporter,”FEBS Letters, 484:92-97, 2000.
Okuda et al., “Identification and characterization of the high-affinity choline transporter,”Nature Neuroscience, 3(2):120-125, 2000.
Okuda et al., “Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate,”J. Biol. Chem., 277(47):45315-43522, 2002.
Phillips, “The challenge of gene therapy and DNA delivery,”Pharm. Pharmacol., 53:1169-1174, 2001.
Schloss et al., “The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues,”Biochem Biophys Res Commun, 198(2):637-645, 1994.
Skolnick et al., “From genes to protein structure and function: novel applications of computational approaches in the genomic era,”Trends in Biotech., 18(1):34-39, 2000.
Smith et al., “The challenges of genome sequence annotation or ‘The devil is in the details,’”Nature Biotech., 15:1222-1223, 1997.
Turk and Wright, “Membrane topology motifs in the SGLT cotransporter family,”J Membr Biol, 159:1-20, 1997.
Wells, “Additivity of mutational effects in proteins,”Biochemistry, 2(37):8509-8517, 1990.
Zoli et al., “Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors,”EMBO Journal, 18(5):1235-1244, 1999.

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