Bisamidine derivatives as thrombin inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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Details

514533, 514538, 514562, 560 10, 560 13, 562429, 562430, A61K 3124, A61K 31195, C07C31712, C07C31714

Patent

active

053289323

ABSTRACT:
The present invention provides new thrombin inhibiting bisamidines derivatives, their pharmaceutically acceptable salts and hydrates, methods for their preparation, pharmaceutical composition, a process for their preparation, and use of the compounds in treatment of thrombosis, ischemia and stroke.

REFERENCES:
patent: 4041156 (1977-08-01), Okamoto et al.
patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4440933 (1984-04-01), Montzka
patent: 4537896 (1985-08-01), Cleason et al.

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