Boots – shoes – and leggings
Patent
1994-12-28
1997-06-03
Voeltz, Emanuel T.
Boots, shoes, and leggings
364497, 364569, G06F 1700
Patent
active
056361360
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a measurement apparatus, more particularly to a measurement apparatus which includes plural measurement units and carries out various measurements in an overlapped manner over the passage of time.
BACKGROUND ART
In the past, an optical measurement method has been known for a measurement apparatus. The method employs a slab-type optical waveguide. The method excites labeled fluorescent bodies which exist in the vicinity of the surface of the optical waveguide using evanescent wave components from the optical waveguide. To actualize the optical measurement method, an apparatus is proposed as is illustrated in FIG. 15. In the apparatus, a test liquid housing chamber 92 is formed in one body at one face of a slab-type optical waveguide 91. An exciting light radiated from a laser light source or the like, which is not illustrated, enters into the optical waveguide 91 through a dichroic mirror 93. Fluorescent light radiated from labeled fluorescent bodies exits through the optical waveguide 91, and is radiated by the dichroic mirror 93 so as to be introduced into a detector 95 through an optical filter 94.
When the above-mentioned arrangement is employed, antibodies 96 are previously fixed on a surface of the optical waveguide 91. Antigens 97 in a test liquid are then bound by the antibodies 96, and then fluorescent labeled antibodies 98 (which are made by labeling antibodies with fluorescent bodies) are bound by the antigens 97. That is, the quantity of bound fluorescent labeled antibodies 98 is determined based upon the quantity of antigens 97 in the test liquid. And, an evanescent wave component is obtained by introducting an exciting light into the optical waveguide 91. Only the label fluorescent bodies 98a of the bound fluorescent labeled antibodies 98 are excited by the evanescent wave component so that the label fluorescent bodies 98a radiate fluorescence. Therefore, the intensity of radiated fluorescence is in proportion to the quantity of the antigens 97 in the test liquid. Further, the fluorescence is guided in the optical waveguide 91. Consequently, existence or non-existence or a degree of immnoreaction is measured by reflecting only the guided fluorescence by the dichroic mirror 93, cutting off the exciting light component with the optical filter 94, and introducing the fluorescence into the detector 95.
To perform an immunological measurement using the fluorescence immunological measurement apparatus having the above-mentioned arrangement, pre-processing for diluting the test liquid including antigens 97 with a dilution liquid is necessary prior to housing the test liquid and the fluorescent labeled antibodies 98 in the test liquid housing chamber 92.
FIG. 16 is a diagram explaining a conventional method employed in a fluorescence immunological measurement apparatus having six measurement units when the above-mentioned immunity measurement is carried out. In FIG. 16, T1 represents a preparation time until the beginning of a primary reaction, that is, a preparation time until the diluted test liquid is poured in the test liquid housing chamber 92 acting as a reaction vessel. T2 represents the primary reaction time of the immunological reaction, that is, a reaction time for the reception of the antigens 97 in the test liquid by the antibodies 96 which were previously fixed on the surface of the test liquid housing chamber 92. T3 represents a time period from B/F separation to the beginning of a secondary reaction, that is, a time period for discharging the test liquid in the test liquid housing chamber 92 and for pouring reagent which includes fluorescent labeled antibodies 98 in the test liquid housing chamber 92. T4 represents a light measurement time, that is, a time for measuring the fluorescence radiated by the label fluorescent bodies 98a of the fluorescent labeled antibodies 98 which have been received by the antigens 97. In the fluorescent immunological measurement apparatus, when measurement of the six measurement units is carried out usin
REFERENCES:
patent: 5282149 (1994-01-01), Grandome et al.
patent: 5380487 (1995-01-01), Choperena et al.
Field et al., "Overlapped Processing in Wet Chemical Analyzer" IBM Technical Disclosure Bulletin, vol. 19, No. 3, Aug. 1976, pp. 1022-1024.
Kuwada Atsushi
Toida Tatumi
Daikin Industries Ltd.
Kemper M.
Voeltz Emanuel T.
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