Process for the preparation of...

Details Process for the preparation of... Process for the preparation of...

2007-04-19

2008-07-29

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

07405325

ABSTRACT:
A process for the preparation of 4-hydroxyalkylamino-2-nitro-anisoles of the general formula (I)wherein m is 2 or 3;by reaction of a 4-halogeno-3-nitro-aniline of formula (II) with a chloroalkyl-chloroformate of formula (III), alkaline ring closure of the resulting carbamate and nucleophilic replacement of the halogeno atom by a methoxy group to form a derivative of formula (IV), and finally ring opening of the resulting cyclic carbamate by treatment with methanolic alkali metal hydroxide, followed by neutralization with inorganic or organic acids, wherein the complete reaction is executed in a non-aqueous medium; as well as process for the preparation of 2-amino-4-hydroxyalkylamino-anisoles of formula (V)

REFERENCES:
patent: 5508467 (1996-04-01), Bauer et al.
patent: 3536066 (1986-04-01), None
patent: 3806237 (1989-10-01), None
European Search Report, Application No. 06008163.5, dated Oct. 13, 2006 (4 pages).

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