Isothiazole derivatives useful as anticancer agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S326000, C514S372000, C544S367000, C546S209000, C548S213000

Reexamination Certificate

active

07405218

ABSTRACT:
The present invention relates to compounds of the formula 1and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2and R3are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods treating hyperproliferative disorders in mammals by administering the above compounds.

REFERENCES:
patent: 4057416 (1977-11-01), Gibbons
patent: 4059433 (1977-11-01), Gibbons
patent: 5952359 (1999-09-01), Godfrey
patent: 6235764 (2001-05-01), Larson et al.
patent: 6548526 (2003-04-01), Larson et al.
patent: 4425642 (1996-01-01), None
patent: 0578246 (1994-12-01), None
patent: 9220642 (1992-11-01), None
patent: 9921845 (1999-05-01), None
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.

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