Epothilone derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C549S270000, C549S554000, C549S513000, C560S051000, C568S449000

Reexamination Certificate

active

10538200

ABSTRACT:
The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation.

REFERENCES:
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patent: 99/07692 (1999-02-01), None
patent: 99/65913 (1999-12-01), None
patent: 03/022844 (2003-03-01), None
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de Jesus Oliveira et al., “Diastereoselective formation of a quaternary center ij a pyroglutamate derivative. Formal synthesis of Monatin,” Tetrahedron Letters, vol. 42, pp. 6793-6796 (2001).
Chappell et al., “Probing the SAR of dEpoB via Chemical Synthesis: A Total Synthesis Evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B,” J. Org. Chem., vol. 67, pp. 7730-7736 (2002).
Patent Abstracts of Japan, vol. 015, No. 193 (C-0832), May 17, 1991.

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