Thiazolyl-based compounds useful as kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S195000

Reexamination Certificate

active

11633337

ABSTRACT:
The present invention provides thiazolyl-based compounds of formula (I),useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.

REFERENCES:
patent: 4200750 (1980-04-01), Warner, Jr. et al.
patent: 5712279 (1998-01-01), Biller et al.
patent: 5739135 (1998-04-01), Biller et al.
patent: 5760246 (1998-06-01), Biller et al.
patent: 6184231 (2001-02-01), Hewawasam et al.
patent: 6262094 (2001-07-01), Hoefle et al.
patent: 6262096 (2001-07-01), Kim et al.
patent: 6548529 (2003-04-01), Robl et al.
patent: 6596746 (2003-07-01), Das et al.
patent: 6605599 (2003-08-01), Vite et al.
patent: 6706720 (2004-03-01), Atwal et al.
patent: 2002/0065270 (2002-05-01), Moriarty et al.
patent: 2002/0137747 (2002-09-01), Moriarty et al.
patent: 2003/0114504 (2003-06-01), Webster et al.
patent: 2004/0024208 (2004-02-01), Das et al.
patent: 2004/0039033 (2004-02-01), Atwal et al.
patent: 2004/0054186 (2004-03-01), Das et al.
patent: 2004/0073026 (2004-04-01), Das et al.
patent: 2004/0077875 (2004-04-01), Das et al.
patent: 0928790 (1999-07-01), None
patent: WO 00/62778 (2000-10-01), None
patent: WO 01/10865 (2001-02-01), None
patent: WO 02/96905 (2001-03-01), None
patent: WO 01/35959 (2001-05-01), None
patent: WO 01/70671 (2001-09-01), None
patent: WO 01/74811 (2001-10-01), None
patent: WO 02/45652 (2002-06-01), None
Ahn, H.-S. et al., “Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity”, J. Med. Chem., vol. 40, No. 14, pp. 2196-2210 (1997).
Henry, J.R. et al., “p38 mitogen-activated protein kinase as a target for drug discovery”, Drugs of the Future, vol. 24, No. 12, pp. 1345-1354 (1999).
Moreland, L.W. et al., “Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial”, Ann. Intern. Med., vol. 130, No. 6, pp. 478-486 (1999).
Rankin, E.C.C. et al., “The Therapeutic Effects of an Engineered Human Anti-Tumour Necrosis Factor Alpha Antibody (CDP571) in Rheumatoid Arthritis”, British Journal of Rheumatology, vol. 34, No. 4, pp. 334-342 (1995).
Raingeaud, J. et al., “MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway”, Molecular and Cellular Biology, vol. 16, No. 3, pp. 1247-1255 (1996).
Salituro, F.G. et al., “Inhibitors of p38 MAP Kinase: Therapeutic Intervention in Cytokine-Mediated Diseases”, Current Medicinal Chemistry, vol. 6, No. 9, pp. 807-823 (1999).
Zhao, R. et al., “A new facile synthesis of 2-aminothiazole-5-carboxylates”, Tetrahedron Letters, vol. 42, pp. 2101-2102 (2001).

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