RSV polymerase inhibitors

Details RSV polymerase inhibitors RSV polymerase inhibitors

2008-01-29

2008-01-29

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S084000, C514S293000

Reexamination Certificate

active

10975562

ABSTRACT:
Compounds or enantiomers of formula (I) or a salt thereof:wherein R1, R2, R3, R4and R5are as defined herein, are useful for the manufacture of a medicament for the treatment or prevention of respiratory syncytial virus infection in a mammal.

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S. Landry, Structure-Activity-Relationship and Synthetic Aspects of Homophthalimide RSV Polymerase Inhibitors, 87th Canadian Chemistry Conference & Exhibition, Organic Workshop, May 25-28, 2004, London (Ontario) Canada.
J. Bordeleau, et al., New inhibitors of Respiratory Syncitial Virus RNA-dependent RNA Polymerase, 228th, American Chemistry Society National meeting, Aug. 22-26, 2004, Philadelphia, PA, US.
Stephen W. Mason, et al., “Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor”, Nucleic Acids Reseach, vol. 32, No. 16, p4758, 2004.

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