Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-01-01
2008-01-01
Ungar, Susan (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007400, C435S007910
Reexamination Certificate
active
10213633
ABSTRACT:
A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence of the amino acid eicosanoid metabolite indicates the activity of the COX-2 enzyme of the subject. Preferably the amino acid eicosanoid metabolite is a PGH2-Gly or HETE-Gly metabolite. The metabolite may be detected based on metabolism of a COX-2-selective substrate. Preferably, the substrate is a lipoamino acid. More preferably, the lipoamino acid is selected from NAGly, N-arachidonyl-alanine, and δ-arachidonyl aminobutuyic acid.
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Kingsley Philip J.
Kozak Kevin R.
Marnett Lawrence J.
Prusakiewicz Jeffery J.
Myers, Jr. Richard S.
Stites & Harbison PLLC
Ungar Susan
Vanderbilt University
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