Method for increasing plasma high density lipoprotein (HDL)

Details Method for increasing plasma high density lipoprotein (HDL) Method for increasing plasma high density lipoprotein (HDL)

1985-02-25

1986-08-19

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

046070427

ABSTRACT:
This invention concerns the use in the treatment or prevention of atherosclerotic disorders and/or coronary heart disease of compounds of formula ##STR1## represents a ring system of formula ##STR2## wherein R.sup.1 represents hydrogen, methyl or benzyl, R.sup.2 represents hydrogen or methyl, R.sup.3 represents hydrogen or methoxy, R.sup.5 represents phenyl, 3-indolyl, 2-furyl, diphenylmethyl, benzyloxy, or phenyl monosubstituted by chlorine, bromine, lower alkyl, carboxy, methylenedioxy, trifluoromethyl or phenyl, or represents phenyl substituted up to three times by lower alkoxy, A represents an ethylene or a 1-oxoethylene biradical, and Z is an oxo- group or, when A is ethylene and R.sup.5 is phenyl, may also represent two hydrogen atoms, and X is an anion of a pharmaceutically acceptable acid.

REFERENCES:
patent: 4428954 (1984-01-01), Cavalla et al.
J. L. Archibald, "Indoramin" from Pharmacology of Antihypertensive Drugs, A. Scriabine, ed., (Raven Press, New York, 1980).
Weidmann et al., Hypertension, Part II, vol. 5, No. 5, Sep./Oct. 1983, pp. III-120 to III-131.
Harvard et al., J. Card. Pharmac., vol. 4, Supp. 2, pp. 5238-5241 (1982).
W. Singleton et al., Amer. Heart Journal, Nov. 1983, pp. 1265-1268.

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