Quinoline derivatives which are 5-hydroxytryptamine antagonists

Details Quinoline derivatives which are 5-hydroxytryptamine antagonists Quinoline derivatives which are 5-hydroxytryptamine antagonists

1983-04-06

1986-08-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, A61K 3147, C07D21522

Patent

active

046070400

ABSTRACT:
Compounds of the formula: ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, which may optionally bear one or two methyl substituents, or for --(CH.sub.2).sub.3 --, R.sup.1 stands for a defined (3-4C)alkyl radical, a cyclopropyl radical, or a phenyl radical which may optionally bear a defined substituent, and R.sup.2 and R.sup.3, which may be the same or different, stand for a methyl or ethyl radical, and pharmaceutically-acceptable acid-addition salts thereof. Process for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.

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