Pseudomonas exotoxin A-like chimeric immunogens

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S260100, C424S190100, C424S133100, C424S183100, C424S184100, C424S192100, C424S193100, C530S350000

Reexamination Certificate

active

09462682

ABSTRACT:
This invention providesPseudomonasexotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain ofPseudomonasexotoxin. Methods of eliciting an immune response using these immunogens also are provided.

REFERENCES:
patent: 4545985 (1985-10-01), Pastan et al.
patent: 4892827 (1990-01-01), Pastan et al.
patent: 4958009 (1990-09-01), Bjorn et al.
patent: 5082927 (1992-01-01), Pastan et al.
patent: 5190873 (1993-03-01), Lernhardt et al.
patent: 5206353 (1993-04-01), Berger et al.
patent: 5328984 (1994-07-01), Pastan et al.
patent: 5428143 (1995-06-01), Berger et al.
patent: 5458878 (1995-10-01), Pastan et al.
patent: 5512658 (1996-04-01), Pastan et al.
patent: 5573916 (1996-11-01), Cheronis et al.
patent: 5587455 (1996-12-01), Berger et al.
patent: 5602095 (1997-02-01), Pastan et al.
patent: 5608039 (1997-03-01), Pastan et al.
patent: 5612036 (1997-03-01), Hodges et al.
patent: 5696237 (1997-12-01), FitzGerald et al.
patent: 5705156 (1998-01-01), Pastan et al.
patent: 5705163 (1998-01-01), Pastan et al.
patent: 5821238 (1998-10-01), Pastan et al.
patent: 5843882 (1998-12-01), Boyd et al.
patent: 5854044 (1998-12-01), Pastan et al.
patent: 5863745 (1999-01-01), Fitzgerald et al.
patent: 5869045 (1999-02-01), Hellstrom et al.
patent: 5935580 (1999-08-01), Ladant et al.
patent: 5965406 (1999-10-01), Murphy
patent: 5980895 (1999-11-01), Pastan et al.
patent: 5980896 (1999-11-01), Hellstrom et al.
patent: 5990296 (1999-11-01), Pastan et al.
patent: 6011002 (2000-01-01), Pastan et al.
patent: 6020145 (2000-02-01), Hellstrom et al.
patent: 6022950 (2000-02-01), Murphy
patent: 6051405 (2000-04-01), FitzGerald et al.
patent: 6074644 (2000-06-01), Pastan et al.
patent: 6083502 (2000-07-01), Pastan et al.
patent: 6086900 (2000-07-01), Draper
patent: 6090388 (2000-07-01), Wang
patent: 6099842 (2000-08-01), Pastan et al.
patent: 6140066 (2000-10-01), Lorberboum-Galski et al.
patent: 6146631 (2000-11-01), Better et al.
patent: 6303120 (2001-10-01), Danishefsky et al.
patent: 6423513 (2002-07-01), Fitzgerald
patent: 6426075 (2002-07-01), Fitzgerald
patent: 6498233 (2002-12-01), Wels et al.
patent: 6531133 (2003-03-01), Lorberboum-Galski et al.
patent: 6783761 (2004-08-01), Grimes et al.
patent: 6881718 (2005-04-01), FitzGerald et al.
patent: 2002/0106370 (2002-08-01), Cardy et al.
patent: 2004/0247617 (2004-12-01), Liao et al.
patent: 2005/0079171 (2005-04-01), FitzGerald et al.
patent: 0583794 (1987-09-01), None
patent: 0 439 954 (1990-12-01), None
patent: 439954 (1991-08-01), None
patent: 95/31483 (1995-11-01), None
patent: WO 95/31483 (1995-11-01), None
patent: WO 97/13529 (1997-04-01), None
patent: WO 98/20135 (1998-05-01), None
Ashorn, Per et al, Proc. Nat'l Acad. Sci, (USA), vol. 87, p. 8889-8893, Nov. 1990.
Chaudhary, VK et al, Nature, vol. 335, Sep. 22, 1988, pp. 369-372.
Cryz et al (1995)Vaccine, vol. 13, pp. 67-71.
Moore, Chapter 2, p. 63-67, Synthetic Peptides Alesers Guide, WH Freeman & Co, N.Y.
Swiss Prot Accession No. P11439,Pseudomonas aerginosaexotoxin A amino acid sequence entered in Oct. 1989.
Cryz et al, 1995, Vaccine, vol. 13(1), pp. 67-71, Human immunodeficiency virus-1 principle neutralizing domain peptide-toxin A conjugate vaccine.
Catasti, P et al, The Journal of Biological Chemistry, vol. 270(5), Feb. 3, 1995, 2224-2232, Local and Global Structural Properties of the HIV-MN V3 Loop.
Donnelly, John J et al, PNAS, 1993, vol. 90, pp. 3530-3534, Apr. 1993.
Brinkmann and Pastan, “Immunotoxins against cancer,”Biochimica et Biophysica Acta, 1198:27-45 (1994).
Chaudhary, V.K. et al., “Pseudomonasexotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity,”Proc. Natl. Acad. Sci. USA, 87:308-312 (1990).
Cryz, Jr., S.J. et al., “Human immunodeficiency virus-1 principal neutralizing domain peptide-toxin A conjugate vaccine,”Vaccine, 13:67-71 (1995).
Cryz, Jr., S.J. et al., “Safety and Immunogenicity of aPseudomonas aeruginosaO-Polysaccharide Toxin A Conjugate Vaccine in Humans,”J. Clin. Invest., 80:51-56 (1987).
Cryz, Jr., S.J. et al., “Safety and Immunogenicity ofEscherichia coliO18 O-Specific Polysaccharide (O-PS)-Toxin and O-PS-Cholera Toxin Conjugate Vaccines in Humans,”J. Infectious Disease, 163:1040-1045 (1990).
FitzGerald, D.J. et al., “Characterization of V3 Loop-Pseudomonas Exotoxin Chimeras,”J. of Biol. Chem., 273(16):9951-9958 (1998).
Lukac, M. et al., “Toxoid ofPseudomonas aeruginosaExotoxin A Generated by Deletion of an Active-Site Residue,”Infection and Immunity, 56(12):3095-3098 (1988).
Que, J.U. et al., “Effect of Carrier Selection on Immunogenicity of Protein Conjugate Vaccines againstPlasmodium falciparumCircumsporozoites,”Infection and Immunity, 56:2645-2649 (1988).
Reiter et al., “Engineering antibody Fv fragments for cancer detection and therapy: Disulfide-stabilized Fv -fragments,”Nature Biotechnology, 14:1239-1245 (1996).
Backstrom, M. et al., “Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit,”Gene, 149:211-217 (1994).
Berman, P.W. et al., “Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160,”Nature, 345:622-625 (1990).
Eaton, A.M. et al., “An Anti-gp41 Human Monoclonal Antibody That Enhances HIV-1 Infection in the Absence of Complement,”Aids Res. Hum. Retroviruses, 10:13-18(1994).
Emini, E.A. et al., “Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody,”Nature, 355:728-730 (1992).
Evans, D.J. et al., “An engineered poliovirus chimaera broadly reactive HIV-1 neutralizing anitboies,”Nature, 339:385-388 (1989).
Fontenot, J.D. et al., “Human immunodeficiency virus (HIV) antigens: Structure and serology of multivalent human mucin MUC1-HIV V3 chimeric proteins,”Proc. Natl. Acad. Sci. USA, 92:315-319.
Javaherian, K. et al., “Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein,”Proc. Natl. Acad. Sci. USA, 86:6768-6772 (1989).
Kovacs, J.A. et al., “Induction of Humoral and Cell-mediated Anti-Human Immunodefieiency Virus (HIV Responses in HIV Sero-negative Volunteers by Immunization with Recombinant gp160,”J. Clin. Invest., 92:919-928 (1993).
Mitchell, W.M. et al., “Antibodies to the putative SIV infection-enhancing domain diminish beneficial effects of an SIV gp160 vaccine in rhesus macaques,”Aids, 9:27-34 (1995).
Montefiori, D.C. et al., “Neutralizing and Infection-Enhancing Antibody Responses to Human Immunodeficiency Virus Type 1 in Long-Term Nonprogressors,”J. Infect. Dis., 173:60-67.
Rusche, J.R. et al., “Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120,”Proc. Natl. Acad. Sci. USA, 85:3198-3202 (1988).
Steimer, K.S. et al., “Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120,”Science, 254:105-108 (1991).
Toth, F.D. et al., “Antibody-dependent enhancement of HIV-1 infection in human term syncytiotrophoblast cells cultured in vitro,”Clin. Exp. Immunol., 96:389-394.
Wang, C.Y. et al., “Long-Term High-Titer Neutralizing Activity Induced by Octameric Synthetic HIV-1 Antigen,”Science, 254:285-288 (1991).
White-Scharf, M.E. et al., “Broadly Neutralizing Monoclonal Antibodies to the V3 Region of HIV-1 Can Be Elicited Peptide Immunization,”Virology, 192:197-206 (1993).
U.S. Appl. No. 09/462,713, Fitzgerald.
Choe, et al. Cancer Res “B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form ofPseudomonasexotoxin is fused to the Fab fragment of monocional antibody B3” Jul. 1994 vol. 54, Issue 13 pp. 3460-3467.
Kreitman, et al. Bioconjug Chem “Properties of Chimeric Toxins with Two Recognition Domains: Interleukin 6 and tran

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pseudomonas exotoxin A-like chimeric immunogens does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pseudomonas exotoxin A-like chimeric immunogens, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pseudomonas exotoxin A-like chimeric immunogens will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3934401

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.