Nonpeptide substituted spirobenzoazepines as vasopressin...

Details Nonpeptide substituted spirobenzoazepines as vasopressin... Nonpeptide substituted spirobenzoazepines as vasopressin...

2008-04-29

2008-04-29

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S586000, C540S543000

Reexamination Certificate

active

11564471

ABSTRACT:
The invention is directed to nonpeptide substituted benzodiazepines of Formula I,wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

REFERENCES:
patent: 7238687 (2007-07-01), Chen et al.

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