Biomimetic 3-dimensional scaffold with metabolic stream...

Details Biomimetic 3-dimensional scaffold with metabolic stream... Biomimetic 3-dimensional scaffold with metabolic stream...

2008-07-01

2008-07-01

Sullivan, Daniel M (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

C435S325000, C435S373000, C435S395000, C435S401000

Reexamination Certificate

active

11184290

ABSTRACT:
A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a plurality of layers that include spacers and spaced openings such that at least a first set of parallel chambers is formed when the roll is formed, the chambers being manifolded to a first inlet and a first outlet. The bio-artificial organ may further include at least a second chamber, the second chamber being isolated from the first set of chambers by at least a cell barrier. A method for assembling a bio-artificial organ comprises a) providing a substrate for cell culture capable of forming a roll, the substrate having a surface, b) patterning the surface of the substrate, c) seeding cells onto the substrate, and d) reeling the substrate into a cylindrical roll.

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