Compositions and methods for regulating bacterial pathogenesis

Details Compositions and methods for regulating bacterial pathogenesis Compositions and methods for regulating bacterial pathogenesis

2008-01-29

2008-01-29

Navarro, Mark (Department: 1645)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S252300, C435S007320, C422S067000, C424S093200

Reexamination Certificate

active

10409783

ABSTRACT:
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

REFERENCES:
patent: 4107121 (1978-08-01), Stoy
patent: 4692417 (1987-09-01), Webster
patent: 4861709 (1989-08-01), Ulitzur et al.
patent: 4895566 (1990-01-01), Lee
patent: 4917686 (1990-04-01), Bayston et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 5103306 (1992-04-01), Weiman et al.
patent: 5166057 (1992-11-01), Palese et al.
patent: 5196318 (1993-03-01), Baldwin et al.
patent: 5593827 (1997-01-01), Bycroft et al.
patent: 5612184 (1997-03-01), Rosson
patent: 5637113 (1997-06-01), Tartaglia et al.
patent: 5658748 (1997-08-01), Mayra-Makinen et al.
patent: 5759798 (1998-06-01), Dunlap
patent: 5788979 (1998-08-01), Alt et al.
patent: 5902283 (1999-05-01), Darouiche et al.
patent: 5925552 (1999-07-01), Keogh et al.
patent: 6017722 (2000-01-01), Becvar et al.
patent: 6020121 (2000-02-01), Bao
patent: 6057288 (2000-05-01), Pearson
patent: 6117485 (2000-09-01), Woodhall et al.
patent: 6197591 (2001-03-01), Stutzman-Engwall et al.
patent: 6218157 (2001-04-01), Kimoto et al.
patent: 6395282 (2002-05-01), Kende et al.
patent: 6537558 (2003-03-01), Kaniga
patent: 6559176 (2003-05-01), Bassler et al.
patent: 6864067 (2005-03-01), Bassler et al.
patent: 2003/0054512 (2003-03-01), Cronan et al.
patent: 2003/0165932 (2003-09-01), Taga et al.
patent: 2005/0227345 (2005-10-01), Whiteley et al.
patent: WO 98/13328 (1998-04-01), None
patent: WO 98/40346 (1998-09-01), None
patent: WO 98/58075 (1998-12-01), None
patent: WO 99/00349 (1999-01-01), None
patent: WO 99/01119 (1999-01-01), None
patent: WO 99/29647 (1999-06-01), None
patent: WO 99/47545 (1999-09-01), None
patent: WO 00/11021 (2000-03-01), None
patent: WO 01/85664 (2001-11-01), None
Jones, S et al, The EMBO Journal vol. 12(6), pp. 2477-2482, 1993, The lux autoinducer regulates the production of exoenzyme virulence determinants inErwinia carotovoraandPseudomonas aeruginosa.
Bassler et al, Mol. Microbiology, vol. 13(2) 1994, pp. 273-286.
Jones et al, reference of record.
Coulthurst, SJ et al, Molecular Plant Pathology, 2006, vol. 7(1), pp. 31-45, Genetic and proteomic analysis of the role of luxS in the enteric phytopathogenErwinia carotovora.
Ohtani, Kaori et al, Molecular Microbiology, vol. 22(1), pp. 171-179, 2002, The luxS gene is involved in cell-cell signalling for toxin production inClostridium perfringens.
Winzer, K et al, Microbiology, 2002, vol. 148, pp. 909-922, LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H) furanone.
Henke, Jennifer M et al, Bacterial social engagement, Trends in Cell Biology, vol. 14(11), Nov. 2004, pp. 648-656.
Wei, Jun-Rong et al, International Journal of Medical Microbiology, vol. 296, pp. 117-124, 2006, N-Acylhomoserine lactone dependent cell to cell communication and social behavior in the genusSerratia.
Alm, RA et al, Nature, vol. 397, Jan. 14, 1999, pp. 176-180 and p. 719, Genomic sequence comparison of two unrealted isolates of the human gastric pathogenHelicobacter pylori.
Surette, MG et al, PNAS, USA, vol. 95, pp. 7046-7050, Jun. 1998, Quorum sensing inEscherichia coliandSalmonella typhimurium.
Surette, Michael G et al, PNAS (USA), Feb. 1999, vol. 96, pp. 1639-1644, Quarum sensing inEscherichia coli, Salmonella typhimuriumandVibrio harveyi: A new family of genes responsible for autoinducer production.
Nitzan, Y et al, Photochemistry and Photobiology, Apr. 1999, Photoinactivation ofDeinococcus radiodurans: An unusual gram positive microorganism. (abstract only).
Wei, Jun-Rong et al, International Journal of Medical Microbiology, vol. 296, pp. 117-124, N-acylhomoserine lactone-dependent cell to cell communicaiton and social behavior in the genusSerratia.
Henke, Jennifer M et al, Trends in Cell Biology, vol. 14(11), pp. 648-656, Bacterial social engagements.
Brint, J. Mark et al., “Synthesis of Multiple Exoproducts inPseudomonas aeruginosaIs under the Control of RhlR-Rhll, Another Set of Regulators in Strain PAO1 with Homology to the Autoinducer-Responsive LuxR-Luxl Family,” Journal of Bacteriology, Dec. 1999, pp. 7155-7163.
International Search Report for International Application No. PCT/US99/28751, dated Mar. 14, 2000.
Ochsner, Urs A. et al., “Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis inPseudomonas aeruginosa,” Proc. Natl. Acad. Sci. USA, vol. 92, Jul. 1995, pp. 6424-6428.
Ahmer et al., “Salmonella typhimuriumEncodes an SdiA Homolog, a Putative Quorum Sensor of the LuxR Family, That Regulates Genes on the Virulence Plasmid”Journal of Bacteriology, pp. 1185-1193 (Mar. 1998).
Allart et al., “The catalytic mechanism of adenosylhomocysteine/methylthioadenosine nucleosidase fromEscherichia coli: Chemical evidence for a transition state with a substantial oxocarbenium character”Eur. J. Biochem., 256, pp. 155-162 (1998).
Baines et al., “Purification of Immunoglobulin G (IgG)”Methods in Molecular Biology, vol. 10: Immunochemical Protocols, Ed: M. Manson (1992).
Bassler et al. “Intercellular Communication in Marine Vibrio Species: Density-Dependent Regulation of the Expression of Bioluminescence”Two-Component Signal Transduction, pp. 431-445 (1995).
Bassler et al. “Intercellular signaling inVibrio harveyi: sequence and function of genes regulating expression of luminescence”Molecular Microbiology, 9(4) 773-786 (1993).
Bassler et al., “A Multichannel Two-Component Signaling Relay Controls Quorum Sensing inVibrio harveyi” Cell-Cell Signaling in Bacteria, pp. 259-273 (1999).
Bassler et al., “Cross-Species Induction of Luminescence in the Qurorum-Sensing BacteriumVibrio harveyi”, Journal of Bacteriology, vol. 179, No. 12, pp. 4043-4045 (Jun. 1997).
Bassler, “How bacteria talk to each other: regulation of gene expression by quorum sensing”Current Opinion in Microbiology, 2:582-587 (1999).
Bassler, Bonnie L., Current Opinion in Microbiology, vol. 2, pp. 582-587, 1999.
Bassler, et al., Molecular Microbiology, 12(2):273-286.
Bassler, et al., Molecular Microbiology, vol. 9(4), pp. 773-786, 1993.
Becker et al. (1997) “Evidence for Interspecies Communication and its Potential Role in Pathogen Suppression in a Naturally Occurring Disease Suppressive Soil”,Canadian Journal of Microbiology, 43:985-990.
Bitter et al. “Expression and Secretion Vectors for Yeast”Methods in Enzymology, vol. 153, pp. 516-544 (1987).
Bitter, “Heterologous Gene Expression in Yeast”Methods in Enzymology, vol. 152, pp. 673-684 (1987).
Blattner et al. “The Complete Genome Sequence ofEscherichia coliK-12”Science, vol. 277, pp. 1453-1462 (1997).
Blattner, et al., Science vol. 277, vol. 5331, Sep. 1997, pp. 1453-1474, 1997.
Brückner et al. “Regulation of the inducible chloramphenicol acetyltransferase gene of theStaphylococcus aureusplasmid pUB112”The EMBO Journal, vol. 4 No. 9, pp. 2295-2300 (1985).
Caetano-Annollés, “Amplifying DNA with Arbitrary Oligonucleotide Primers”PCR Methods and Applications, 3:85-94 (1993).
Cheung et al. “Diminished Virulence of a sar-lagr-Mutant ofStaphylooccus aureusin the Rabbit Model of Endocarditis”The Journal of Clinical Investigation, Inc., vol. 94, pp. 1815-1822 (1994).
Conner et al. “Detection of sickle cell βs-globin allele by hybridization with synthetic oligonucleotides”Proc. Natl. Acad. Sci. USA, vol. 80, pp. 278-282 (Jan. 1983).
Cornell and Riscoe, “Cloning and expression ofEscherichia coli5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase Identification of

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