Shogaol compound and tyrosinase activity inhibitor...

Details Shogaol compound and tyrosinase activity inhibitor... Shogaol compound and tyrosinase activity inhibitor...

2008-04-08

2008-04-08

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S060000, C568S309000, C568S716000, C568S763000, C568S766000, C514S475000, C514S543000

Reexamination Certificate

active

10549117

ABSTRACT:
The compound represented by the following formula (1):wherein A, B, R1, R2, R3 and Z are as defined in the specification is analogous to shogaol and gingerol useful in the fields of foods, medicines, quasi-drugs, cosmetics, etc., and more highly active in tyrosinase activity inhibition, etc. than shogaol and gingerol.

REFERENCES:
patent: 2001-131033 (2001-05-01), None
T.Nakazawa, K.Ohsawa□□Metabolism of [6]-gingerol in rats□□Life Sciences 70 (2002) 2165-2175.
T.Nakazawa, K.Ohsawa,□□Metabolism of [6]-gingerol in rats,□□Life Sciences 2002, 70, 2165-2175.
Sang-Sup Lee,□□Re-examination of 6-shogaol biotransformation byAspergillus niger□□Archives of Pharmacal Research 1995, 18(2), 136-7.
Takahashi et al., “Biotransformation of 6-gingerol and 6-shogaol byAspergillus niger”, Phytochemistry, vol. 34, No. 6, 1993, pp. 1497-1500.
Lee et al., “Biotransformation of dehydroparadols byAspergillus niger”, Database accession No. 1996:64711.
Takahiro Nakazawa, et al., “Life Sciences”, 2002, pp. 2165-2175, vol. 70, No. 18.
International Search Report dated Jul. 13, 2004.

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