Method of reducing TNF.alpha. levels with amino substituted 2-(2

Details Method of reducing TNF.alpha. levels with amino substituted 2-(2 Method of reducing TNF.alpha. levels with amino substituted 2-(2

1996-07-24

1997-06-03

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546201, A61K 31445, C07D40104

Patent

active

056355173

ABSTRACT:
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines substituted with amino in the benzo ring reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline.

REFERENCES:
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patent: 5463083 (1995-10-01), Muller
N. Ake Jonsson, Chemical Structure and Teratogenic Properties: A Review Of Available Data On Structure-Activity Relationships and Mechanism Of Action Of Thalidomide Analogues, Acta Pharm. Suicica, vol. 9, pp. 521-542 (1972).
H. Koch, The Arene Oxide Hypothesis Of Thalidomide Action. Considerations On the Molecular Mechanism Of Action Of the Classical Teratogen, Sci. Pharm., vol. 49, pp. 67-99 (1981).
L. Sekut et al., Pathophysiology and Regulation Of TNF-.alpha. In Inflammation, DN&P 9(5), pp. 261-269, (1996).
Smith, R.L.; Fabro, S.; Schumacher, H. and William, R.T.; Studies on the relationship between the Chemical Structured and Embryotoxic Activity Of Thalidomide and Related Compounds. A Symposium on Embryotoxic Activity of dough, edited by Pobinson, J.M. et al. 1965, pp. 194-209. See p. 202, Table 6.

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