Treatment of gynecological malignancies with biologically active

Details Treatment of gynecological malignancies with biologically active Treatment of gynecological malignancies with biologically active

1995-05-02

1997-06-03

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, A61K 3600, C07K 1400

Patent

active

056354797

ABSTRACT:
A process for treating a gynecological malignancy in a host which comprises administering to the host at least one biologically active amphiphilic peptide or protein. The peptide or protein may be administered intralesionally, intravenously, or intraperitoneally, whereby the peptide or protein may inhibit, prevent, or destroy the growth of the gynecological malignancy, such as an ovarian cancer, uterine cancer, or cervical cancer.

REFERENCES:
patent: 4810777 (1989-03-01), Zasloff
patent: 4962277 (1990-10-01), Cuervo et al.
patent: 5073542 (1991-12-01), Zasloff
Ozols et al., Kinetic Characterization and Response to Chemotherapy in a Transplantable Murine Ovarian Cancer, Cancer Research, vol. 39, No. 8, CNREAB 8, pp. 2909-3288 (1979).
Cecil's Textbook of Medicine, ed. Wyngaarden, Smith, Jr. and Bennett, pp. 1395-1397 (19th Edition).
Baker et al., "Anticancer Efficacy of Magainin2 and Analogue Peptides," Cancer Research, vol. 53, pp. 3052-43057, (Jul. 1, 1993).

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