N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-N-phenylamines...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S331000

Reexamination Certificate

active

11433312

ABSTRACT:
The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.

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patent: WO-01/72745 (2001-10-01), None
Blain et al., Differential Interaction of the Cyclin-dependent kinase (Cdk) Inhibitor p27kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4, The Journal of Biological Chemistry, vol. 272, No. 41, pp. 25863-25872, 1997.
LuValle et al., Cell Cycle Control in Growth Plate Chondrocytes, Frontiers in Bioscience 5, d493-503, May 2001.
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Traxler, Protein Tyrosine Kinase Inhibitors in cancer treatment, Expert Opinion on Therapeutic Patents, 7(6):571-588, 1997.
Paul, Rolf et al., “Preparation of SubstitutedN-Phenyl-4-aryl-2-pyrimidinamines as Mediator Release Inhibitors,”J. Med. Chem., vol. 36:2716-2725 (1993).
Zimmermann, Jürg et al., “Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC),”Arch. Pharm. Pharm. Med. Chem., vol. 329:371-376 (1996).

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