Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-07-01
2008-07-01
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S367000, C514S412000, C548S453000, C548S153000, C546S276700
Reexamination Certificate
active
11674349
ABSTRACT:
The present invention discloses and claims compounds of formula (I) and formula (II),as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.
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Gairns, et al. “Photochemical Conversion of 3-Azido-2-vinylthiophenes into thienopyrroles and of 2-Azidostyrenes into Indoles. High Migratory Aptitutde of Sulphur Substituents”, J. Chem. Soc. Perkin Trans. I, pp. 501-506 (1986).
Mashhoon, N., et. al., Crystal Structure of a Conformation-Selective Casein Kinase-1 Inhibitor, J. Biol. Chem. vol. 275, No. 26, (2000) pp. 20052-20060.
Meggio, F., et. al., Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1 , European Journal of Niochemistry vol. 187, No. 1, (1990) pp. 89-94.
Ning, K., et. al., Circadian Regulation of GABAA Receptor Function by CKI-Epsilon-CKI delta in the rat Suprachiasmatic Nuclei, Nature Neuroscience, Nature America, vol. 7, No. 5, (2004).
6-phenylsulfanyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyi esters, Database Beilstein XP002366005 Database Accession Nos. 5099280, 5108767, 5110689 (BRN's). & J. Chem. Soc. Perkin Trans. 1, 1986, pp. 501-506.
Chiang Yulin
Collar Nicola Dawn
Fink David Marc
Anderson Rebecca L
Aventis Pharmaceuticals Inc.
Barker Michael P
Bell Craig M.
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