Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2008-09-30
2008-09-30
Helms, Larry R. (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S142100
Reexamination Certificate
active
10719006
ABSTRACT:
The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
REFERENCES:
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4975369 (1990-12-01), Beavers et al.
patent: 5202238 (1993-04-01), Fell et al.
patent: 5643745 (1997-07-01), Stuart
patent: 5683899 (1997-11-01), Stuart
patent: 5695965 (1997-12-01), Stuart et al.
patent: 5916771 (1999-06-01), Hori et al.
patent: 6207418 (2001-03-01), Hori et al.
patent: 6420140 (2002-07-01), Hori et al.
patent: 6475487 (2002-11-01), Hastings et al.
patent: 6475787 (2002-11-01), Wood et al.
patent: 6677138 (2004-01-01), Hori et al.
patent: 2003/0022291 (2003-01-01), Hori et al.
patent: 2004/0053363 (2004-03-01), Ryll et al.
patent: 273 889 (1988-07-01), None
patent: 0 088 994 (1991-06-01), None
patent: WO 86/01533 (1986-03-01), None
patent: WO 92/15322 (1992-09-01), None
patent: WO 93/19172 (1993-09-01), None
patent: WO 93/25663 (1993-12-01), None
patent: WO 94/02602 (1994-02-01), None
patent: WO 95/02686 (1995-01-01), None
patent: WO 95/30739 (1995-11-01), None
Morrison et al. 1988. Clinical Chemistry. 34:1668-1675.
Orlandi et al (Proc. Natl. Acad. Sci. USA, 86:3833-3837, 1989).
Darnell et al (Molecular Cell Biology, 1990, 2nd ed. pp. 1005, 1009).
Trill et al (Current Opinion in Biotechnology. 1995. 6:553-560; IDS—Jun. 22, 2006).
Merriam-Webster Online: Definition of “amplification” pp. 1-2.
Kohler. Proc. Natl. Acad. Sci. 1980, 77:2197-2199.
Haas and Wabl. Proc. Natl. Acad. Sci. 1984, 81:7185-7188.
Bebbington. Methods: A Companion to Methods of Enzymology, 1991. 2(2):136-145.
Trill et al. “Production of monoclonal antibodies in COS and CHO cells.”Biotechnology. 8:553-560 (1995).
Wood, et al., “High Level Synthesis of Immunoglobulins in Chinese Hamster Ovary Cells,” J.Immunol. 145(9):3011-3016 (Nov. 1, 1990).
Bebbington, C.R., (1991) “Expression of Antibody Genes in Nonlymphoid Mammalian Cells,” Methods: A Companion to Methods Enzymol. 2:136-145.
Bebbington, C.R., et al., (1992) “High-level Expression of a Recombinant Antibody from Mycloma Cells Using a Glutamine Synthetase Gene As An Amplifiable Selectable Marker,” Bio/Teclinology 10:169-175.
Caron, P.C., et al., (1992)“Engineered Humanized Dimeric Forms of IgG Are More Effective Antibodies,” J. Fxp. Med. 176:1191-1195.
Cattanco, A. and Neuberger, M.S., (1987) “Polymeric Immunoglobulin M Is Secreted by Transfectants of Non- lymphoid Cells in the Absence of Immunoglobulin J Chain,”EMBO J. 6:2753-2758.
Cockett, M.I., et al., (1990) “High-level Expression of Tissue Inhibitor of Metalloproteinases in Chinese Hamster Ovary Cells Using Glutamine Synthetase Game Amplifica-tion,” Bio/Teclznology' 8:662-667.
Graham, FL., and Vander Eb, A.J., (1973) “A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA,” Wrology 52:456˜67.
Riechmann, L. et al., (1988) “Reshaping Human Antibodies for Therapy,” Nature 332:323-327.
Kranenborg, et al., “Development and Characterization of Anti-Renal Cell Carcinoma XAntichelate Bispecific Mono-clonal Antibodies for Tw˜Phase Targeting of Renal Cell Carcinoma,” Cancer Research (Dec. 1995), vol. 55, No. 23, pp. 5864S-5867S.
Cao, et al., “A Rapid Non-Selective Method to GenerateQuadromas by Microelectrofusion,” J. JYnmunol. Methods (Nov. 16, 1995), vol. 187, No. 1, pp. 1-7.
Salazar-Kish, et al., “Comparison of a Quadroma and its Parent Hybridomas in Fed Batch Culture,” A Bi˜echnniogy (1993), vol. 30, No. 3, pp. 351-365.
Bos, et al., “Enhanced Transfusion of a Bacterial Plasmid of Hybrid Hybridoma (Quadroma Cell) Lines,” Hybridotna (Feb. 1992), vol. 11, No. 1, pp. 41-51.
Davis Claude Geoffrey
Hori Nobuaki
Jakobovits Aya
Zsebo Krisztina M.
Amgen Fremont Inc.
Helms Larry R.
Knobbe Martens Olson & Bear LLP
Natarajan Meera
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