Process for the preparation of optically active 3-demethylmevalo

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549333, 549369, 549375, 544335, 546268, 546341, C07D31906, C07D40506, C07D23926

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049772791

ABSTRACT:
A process for the preparation of optically active 3-demethylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups.

REFERENCES:
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Lynch et al., Tetrahedron Letters, vol. 28, 1987, pp. 1385-1388.
Rosen et al., Tetrahedron Letters, vol. 42, 1986, pp. 4909-4951.
Prugh et al., Journal of Organic Chemistry, vol. 51, 1986, pp. 648-657.
Guindon et al., Tetrahedron Letters, vol. 26, 1985, pp. 1185-1188.
Sletzinger et al., Tetrahedron Letters, vol. 25, 1985, pp. 2951-2954.
Prugh et al., Tetrahedron Letters, vol. 23, 1982, pp. 281-284.
Yang et al,, Tetrahedron Letters, vol. 23, 1982, pp. 4305-4308.

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