Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a

Details Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a

1979-10-19

1981-09-15

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544237, 544238, 544239, C07D23704, A61K 3150, C07D23726, C07D40104

Patent

active

042897742

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is 4-biphenylyl, 4-phenoxyphenyl or 4-biphenylyl or 4-phenoxyphenyl substituted in the 4'-position by F, Cl, Br or I; R.sup.2 is H, C.sub.1-4 -alkyl, hydroxy-C.sub.1-4 -alkyl or pyridyl; R.sup.3 and R.sup.6 are each H or alkyl of 1-4 carbon atoms, or together are--(CH.sub.2).sub.4 --; and R.sup.4 and R.sup.5 are each H or together are a C--C bond; at least one of the radicals R.sup.2, R.sup.3 and R.sup.6 being other than hydrogen, possess valuable pharmacological properties, e.g., lower lipid levels and are anti-thrombotic.

REFERENCES:
patent: 3682914 (1972-08-01), Tamamoto
patent: 3689652 (1972-09-01), Curran
patent: 3812256 (1974-05-01), Curran
patent: 3822260 (1974-07-01), Curran
patent: 3931177 (1976-01-01), Coates
patent: 4088762 (1978-05-01), Hakim
Fateen et al., J. Chem. U.A.R. 10, 321 (1967).
Fateen et al., Chem. Abs. 70, 3997m (1967).
Kulkarni, Current Science 46, 801-3 (1977).
Curran IV, J. Med. Chem. 17, 273 (1974).
Pitarch et al., European J. Med. Chem. 9, 644 (1974).
Child et al., J. Pharm Sci 66, 466 (1977).

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