Multi-unit ribozyme inhibition of oncogene gene expression

Details Multi-unit ribozyme inhibition of oncogene gene expression Multi-unit ribozyme inhibition of oncogene gene expression

1993-09-15

1997-06-03

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 911, 435 913, 435 9131, 4351723, 4353201, 435372, 536 245, 536 251, 536 253, 514 44, 424450, C12N 508, C12N 516, C12N 1585, C07H 2102

Patent

active

056353855

ABSTRACT:
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210.sup.bcr-abl fusion protein.

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