Method of site-specific alteration of RNA and production of enco

Details Method of site-specific alteration of RNA and production of enco Method of site-specific alteration of RNA and production of enco

1994-11-18

1997-06-03

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 911, 536 231, 536 245, 536 251, 536 253, 935 2, 935 34, 935 36, C12N 1511, C12P 1934, C07H 2100

Patent

active

056353774

ABSTRACT:
A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.

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