Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-02-03
1990-12-11
Brust, Joseph P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548539, 548540, A61K 3140, C07D20708
Patent
active
049771809
ABSTRACT:
A novel prolinal derivative of general formula: ##STR1## wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms, n represents a number 2, 3 or 4, D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluromethyl group posses inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent for amnesia.
REFERENCES:
patent: 4701465 (1987-10-01), Tanaka et al.
patent: 4743616 (1988-05-01), Tanka et al.
Science, 211, (1981), pp. 601-603; Weingartner, et al.
J. Biochem., 94, (1983), pp. 1179-1189; Yoshimoto, et al.
Protein, Nucleic Acid & Enzyme 25(6), 513 (1980); Yoshimoto, et al.
Nippon Nougei Kagaku Kaishi 58(11), 1147 (1984); Yoshimoto, et al.
J. Neurochem., 41, (1983), pp. 69-74; Wilk, et al.
J. Neurochem., 42, (1984), pp. 237-241; Friedman, et al.
Ohno Hiroyuki
Ohuchida Shuichi
Toda Masaaki
Brust Joseph P.
Ono Pharmaceutical Co. Ltd.
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