Process for preparing 2-chlorosulfinylazetidinones

Details Process for preparing 2-chlorosulfinylazetidinones Process for preparing 2-chlorosulfinylazetidinones

1979-06-18

1981-09-15

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603303, 2603474, C07D20508, C07D40512, C07D40912

Patent

active

042896959

ABSTRACT:
Improved process for converting a penicillin sulfoxide ester to a 2-chlorosulfinylazetidin-4-one intermediate which on cyclization affords a 3-exomethylenecepham sulfoxide, wherein the penicillin sulfoxide ester is reacted with an N-chloro halogenating agent in the presence of a cross-linked polyvinylpyridine polymer to provide the 2-chlorosulfinylazetidin-4-one.

REFERENCES:
patent: 4075203 (1978-02-01), Chon
patent: 4081440 (1978-03-01), Kakolja
patent: 4159272 (1979-06-01), Chou
Hallensleber et al., Ang. Chem. Int. Ed. 15, 163, (1976).

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