Process for the preparation of cephalosporin antibiotic

Details Process for the preparation of cephalosporin antibiotic Process for the preparation of cephalosporin antibiotic

2008-03-04

2008-03-04

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C540S222000, C540S225000, C540S227000, C540S228000

Reexamination Certificate

active

10922991

ABSTRACT:
A process for the preparation of cephalosporin antibiotic of the formula (I)which comprises:(i) activating the compound of formula (III) as acid halide in an organic solvent(ii) treating the reaction mass obtained from step (i) with water(iii) separating the organic layer containing the reactive derivative of formula (III) and condensing it with 7-amino cephalosporin derivative by maintaining the pH in the range 5.0-10.0 using an inorganic base of the formula (XV), andiv) cyclizing the compound of formula (XVI)with thiourea in the presence of solvent and salt of organic or inorganic acid at a temperature in the range of −50 to +50° C. to produce compound of formula (I).

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U.S. Appl. No. 11/240,382, filed Oct. 3, 2005.

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